7w70 - Revision history

OCA at 17:37, 29 November 2023

OCA — Wed, 29 Nov 2023 17:37:11 GMT

←Older revision		Revision as of 17:37, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7w70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Kangiella_koreensis_DSM_16069 Kangiella koreensis DSM 16069]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W70 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7w70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Kangiella_koreensis_DSM_16069 Kangiella koreensis DSM 16069]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W70 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w70 OCA], [https://pdbe.org/7w70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w70 RCSB], [https://www.ebi.ac.uk/pdbsum/7w70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w70 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w70 OCA], [https://pdbe.org/7w70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w70 RCSB], [https://www.ebi.ac.uk/pdbsum/7w70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w70 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/C7R5Z1_KANKD C7R5Z1_KANKD]]	+	[https://www.uniprot.org/uniprot/C7R5Z1_KANKD C7R5Z1_KANKD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:44, 7 September 2022

OCA — Wed, 07 Sep 2022 18:44:06 GMT

←Older revision		Revision as of 18:44, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/C7R5Z1_KANKD C7R5Z1_KANKD]]		[[https://www.uniprot.org/uniprot/C7R5Z1_KANKD C7R5Z1_KANKD]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Site-2 proteases are a conserved family of intramembrane proteases that cleave transmembrane substrates to regulate signal transduction and maintain proteostasis. Here, we elucidated crystal structures of inhibitor-bound forms of bacterial site-2 proteases including Escherichia coli RseP. Structure-based chemical modification and cross-linking experiments indicated that the RseP domains surrounding the active center undergo conformational changes to expose the substrate-binding site, suggesting that RseP has a gating mechanism to regulate substrate entry. Furthermore, mutational analysis suggests that a conserved electrostatic linkage between the transmembrane and peripheral membrane-associated domains mediates the conformational changes. In vivo cleavage assays also support that the substrate transmembrane helix is unwound by strand addition to the intramembrane beta sheet of RseP and is clamped by a conserved asparagine residue at the active center for efficient cleavage. This mechanism underlying the substrate binding, i.e., unwinding and clamping, appears common across distinct families of intramembrane proteases that cleave transmembrane segments.
		+
		+	Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.,Imaizumi Y, Takanuki K, Miyake T, Takemoto M, Hirata K, Hirose M, Oi R, Kobayashi T, Miyoshi K, Aruga R, Yokoyama T, Katagiri S, Matsuura H, Iwasaki K, Kato T, Kaneko MK, Kato Y, Tajiri M, Akashi S, Nureki O, Hizukuri Y, Akiyama Y, Nogi T Sci Adv. 2022 Aug 26;8(34):eabp9011. doi: 10.1126/sciadv.abp9011. Epub 2022 Aug, 24. PMID:36001659<ref>PMID:36001659</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7w70" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:39, 7 September 2022

OCA — Wed, 07 Sep 2022 16:39:30 GMT

←Older revision		Revision as of 16:39, 7 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7w70 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the PDZ-C domain fragment of Kangiella koreensis RseP orthologue==
-		+	<StructureSection load='7w70' size='340' side='right'caption='[[7w70]], [[Resolution\|resolution]] 1.15Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7w70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Kangiella_koreensis_DSM_16069 Kangiella koreensis DSM 16069]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W70 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w70 OCA], [https://pdbe.org/7w70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w70 RCSB], [https://www.ebi.ac.uk/pdbsum/7w70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w70 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/C7R5Z1_KANKD C7R5Z1_KANKD]]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kangiella koreensis DSM 16069]]
		+	[[Category: Large Structures]]
		+	[[Category: Miyoshi K]]
		+	[[Category: Nogi T]]

OCA at 08:43, 12 January 2022

OCA — Wed, 12 Jan 2022 08:43:20 GMT

←Older revision		Revision as of 08:43, 12 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7w70 is ON HOLD	+	The entry 7w70 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7w70" [edit=sysop:move=sysop]

OCA — Wed, 08 Dec 2021 08:48:44 GMT

Protected "7w70" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 8 December 2021

OCA: New page: '''Unreleased structure''' The entry 7w70 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Dec 2021 08:48:43 GMT

New page: '''Unreleased structure''' The entry 7w70 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7w70 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]