7w8k - Revision history

OCA at 03:58, 8 September 2022

OCA — Thu, 08 Sep 2022 03:58:46 GMT

←Older revision		Revision as of 03:58, 8 September 2022
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	==Solution structures of a disulfide-rich peptide that can bind mdm2==		==Solution structures of a disulfide-rich peptide that can bind mdm2==
-	<StructureSection load='7w8k' size='340' side='right'caption='[[7w8k~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='7w8k' size='340' side='right'caption='[[7w8k]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7w8k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7w8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W8K FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w8k OCA], [https://pdbe.org/7w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w8k RCSB], [https://www.ebi.ac.uk/pdbsum/7w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w8k ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w8k OCA], [https://pdbe.org/7w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w8k RCSB], [https://www.ebi.ac.uk/pdbsum/7w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w8k ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Fan, S H~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Wu, C L~~]]	+	[[Category: Fan SH]]
-	[[Category: Wu~~, Y P~~]]	+	[[Category: Wu CL]]
-	[[Category: ~~Alpha helix]]~~	+	[[Category: Wu YP]]
-	~~[[Category: Disulfide-rich peptide]]~~	+
-	~~[[Category: Mdm2]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 05:04, 3 August 2022

OCA — Wed, 03 Aug 2022 05:04:33 GMT

←Older revision		Revision as of 05:04, 3 August 2022
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	==Solution structures of a disulfide-rich peptide that can bind mdm2==		==Solution structures of a disulfide-rich peptide that can bind mdm2==
-	<StructureSection load='7w8k' size='340' side='right'caption='[[7w8k]]' scene=''>	+	<StructureSection load='7w8k' size='340' side='right'caption='[[7w8k]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7w8k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W8K FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w8k OCA], [https://pdbe.org/7w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w8k RCSB], [https://www.ebi.ac.uk/pdbsum/7w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w8k ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w8k OCA], [https://pdbe.org/7w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w8k RCSB], [https://www.ebi.ac.uk/pdbsum/7w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w8k ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptides constrained through multiple disulfides (or disulfide-rich peptides, DRPs) have been an emerging frontier for ligand and drug discovery. Such peptides have the potential to combine the binding capability of biologics with the stability and bioavailability of smaller molecules. However, DRPs with stable three-dimensional (3D) structures are usually of natural origin or engineered from natural ones. Here, we report the discovery and identification of CPPC (cysteine-proline-proline-cysteine) motif-directed DRPs with stable 3D structures (i.e., CPPC-DRPs). A range of new CPPC-DRPs were designed or selected from either random or structure-convergent peptide libraries. Thus, for the first time we revealed that the CPPC-DRPs can maintain diverse 3D structures by taking advantage of constraints from unique dimeric CPPC mini-loops, including irregular structures and regular alpha-helix and beta-sheet folds. New CPPC-DRPs that can specifically bind the receptors (CD28) on the cell surface were also successfully discovered and identified using our DRP-discovery platform. Overall, this study provides the basis for accessing an unconventional peptide structure space previously inaccessible by natural DRPs and computational designs, inspiring the development of new peptide ligands and therapeutics.
		+
		+	Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery.,Wu Y, Fan S, Dong M, Li J, Kong C, Zhuang J, Meng X, Lu S, Zhao Y, Wu C Chem Sci. 2022 May 20;13(26):7780-7789. doi: 10.1039/d2sc00924b. eCollection 2022, Jul 6. PMID:35865895<ref>PMID:35865895</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7w8k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fan SH]]	+	[[Category: Fan, S H]]
-	[[Category: Wu CL]]	+	[[Category: Wu, C L]]
-	[[Category: Wu YP]]	+	[[Category: Wu, Y P]]
		+	[[Category: Alpha helix]]
		+	[[Category: Disulfide-rich peptide]]
		+	[[Category: Mdm2]]
		+	[[Category: Unknown function]]

OCA at 05:31, 8 June 2022

OCA — Wed, 08 Jun 2022 05:31:27 GMT

←Older revision		Revision as of 05:31, 8 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7w8k ~~is ON HOLD until Paper Publication~~	+	==Solution structures of a disulfide-rich peptide that can bind mdm2==
-		+	<StructureSection load='7w8k' size='340' side='right'caption='[[7w8k]]' scene=''>
-	~~Authors~~: ~~Fan~~, S.H., Wu, Y.P., Wu, C.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W8K FirstGlance]. <br>
-	~~Description: Solution structures of a disulfide-rich peptide that can bind mdm2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w8k OCA], [https://pdbe.org/7w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w8k RCSB], [https://www.ebi.ac.uk/pdbsum/7w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w8k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Wu, Y.P~~]]	+	__TOC__
-	[[Category: Wu~~, C.L~~]]	+	</StructureSection>
-	[[Category: ~~Fan, S.H~~]]	+	[[Category: Large Structures]]
		+	[[Category: Fan SH]]
		+	[[Category: Wu CL]]
		+	[[Category: Wu YP]]

OCA at 14:14, 22 December 2021

OCA — Wed, 22 Dec 2021 14:14:07 GMT

←Older revision		Revision as of 14:14, 22 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7w8k is ON HOLD	+	The entry 7w8k is ON HOLD until Paper Publication

	Authors: Fan, S.H., Wu, Y.P., Wu, C.L.		Authors: Fan, S.H., Wu, Y.P., Wu, C.L.
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	Description: Solution structures of a disulfide-rich peptide that can bind mdm2		Description: Solution structures of a disulfide-rich peptide that can bind mdm2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Wu, Y.P]]
	[[Category: Wu, C.L]]		[[Category: Wu, C.L]]
	[[Category: Fan, S.H]]		[[Category: Fan, S.H]]
-	[[Category: Wu, Y.P]]

OCA: Protected "7w8k" [edit=sysop:move=sysop]

OCA — Wed, 15 Dec 2021 15:50:50 GMT

Protected "7w8k" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:50, 15 December 2021

OCA: New page: '''Unreleased structure''' The entry 7w8k is ON HOLD Authors: Fan, S.H., Wu, Y.P., Wu, C.L. Description: Solution structures of a disulfide-rich peptide that can bind mdm2 [[Category: ...

OCA — Wed, 15 Dec 2021 15:50:49 GMT

New page: '''Unreleased structure''' The entry 7w8k is ON HOLD Authors: Fan, S.H., Wu, Y.P., Wu, C.L. Description: Solution structures of a disulfide-rich peptide that can bind mdm2 [[Category: ...

New page

'''Unreleased structure'''

The entry 7w8k is ON HOLD

Authors: Fan, S.H., Wu, Y.P., Wu, C.L.

Description: Solution structures of a disulfide-rich peptide that can bind mdm2
[[Category: Unreleased Structures]]
[[Category: Wu, C.L]]
[[Category: Fan, S.H]]
[[Category: Wu, Y.P]]