7w9x - Revision history

OCA at 17:38, 29 November 2023

OCA — Wed, 29 Nov 2023 17:38:13 GMT

←Older revision		Revision as of 17:38, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7w9x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._spizizenii_ATCC_6633_=_JCM_2499 Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W9X FirstGlance]. <br>		<table><tr><td colspan='2'>[[7w9x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._spizizenii_ATCC_6633_=_JCM_2499 Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W9X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.151Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w9x OCA], [https://pdbe.org/7w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w9x RCSB], [https://www.ebi.ac.uk/pdbsum/7w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w9x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w9x OCA], [https://pdbe.org/7w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w9x RCSB], [https://www.ebi.ac.uk/pdbsum/7w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w9x ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:14, 7 December 2022

OCA — Wed, 07 Dec 2022 08:14:41 GMT

←Older revision		Revision as of 08:14, 7 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7w9x is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Bacillus subtilis YugJ in complex with nickel==
		+	<StructureSection load='7w9x' size='340' side='right'caption='[[7w9x]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7w9x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._spizizenii_ATCC_6633_=_JCM_2499 Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W9X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w9x OCA], [https://pdbe.org/7w9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w9x RCSB], [https://www.ebi.ac.uk/pdbsum/7w9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w9x ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A5F2KLJ3_BACIU A0A5F2KLJ3_BACIU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	NAD(H)/NADP(H)-dependent aldehyde/alcohol oxidoreductase (AAOR) participates in a wide range of physiologically important cellular processes by reducing aldehydes or oxidizing alcohols. Among AAOR substrates, furan aldehyde is highly toxic to microorganisms. To counteract the toxic effect of furan aldehyde, some bacteria have evolved AAOR that converts furan aldehyde into a less toxic alcohol. Based on biochemical and structural analyses, we identified Bacillus subtilis YugJ as an atypical AAOR that reduces furan aldehyde. YugJ displayed high substrate specificity toward 5-hydroxymethylfurfural (HMF), a furan aldehyde, in an NADPH- and Ni(2+)-dependent manner. YugJ folds into a two-domain structure consisting of a Rossmann-like domain and an alpha-helical domain. YugJ interacts with NADP and Ni(2+) using the interdomain cleft of YugJ. A comparative analysis of three YugJ structures indicated that NADP(H) binding plays a key role in modulating the interdomain dynamics of YugJ. Noticeably, a nitrate ion was found in proximity to the nicotinamide ring of NADP in the YugJ structure, and the HMF-reducing activity of YugJ was inhibited by nitrate, providing insights into the substrate-binding mode of YugJ. These findings contribute to the characterization of the YugJ-mediated furan aldehyde reduction mechanism and to the rational design of improved furan aldehyde reductases for the biofuel industry.

-	~~Authors~~:	+	Structural and Biochemical Analysis of the Furan Aldehyde Reductase YugJ from Bacillus subtilis.,Cho HY, Nam MS, Hong HJ, Song WS, Yoon SI Int J Mol Sci. 2022 Feb 8;23(3):1882. doi: 10.3390/ijms23031882. PMID:35163804<ref>PMID:35163804</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7w9x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]]
		+	[[Category: Large Structures]]
		+	[[Category: Cho HY]]
		+	[[Category: Hong HJ]]
		+	[[Category: Nam MS]]
		+	[[Category: Song WS]]
		+	[[Category: Yoon SI]]

OCA at 12:36, 29 December 2021

OCA — Wed, 29 Dec 2021 12:36:04 GMT

←Older revision		Revision as of 12:36, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7w9x is ON HOLD	+	The entry 7w9x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7w9x" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:14:38 GMT

Protected "7w9x" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:14, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7w9x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Dec 2021 14:14:37 GMT

New page: '''Unreleased structure''' The entry 7w9x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7w9x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]