7wai - Revision history

OCA at 17:38, 29 November 2023

OCA — Wed, 29 Nov 2023 17:38:23 GMT

←Older revision		Revision as of 17:38, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7wai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WAI FirstGlance]. <br>		<table><tr><td colspan='2'>[[7wai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WAI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.105Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wai OCA], [https://pdbe.org/7wai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wai RCSB], [https://www.ebi.ac.uk/pdbsum/7wai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wai ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wai OCA], [https://pdbe.org/7wai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wai RCSB], [https://www.ebi.ac.uk/pdbsum/7wai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wai ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:23, 21 December 2022

OCA — Wed, 21 Dec 2022 09:23:06 GMT

←Older revision		Revision as of 09:23, 21 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wai is ~~ON HOLD until 2024~~-06-14	+	==Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS)==
		+	<StructureSection load='7wai' size='340' side='right'caption='[[7wai]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7wai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WAI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wai OCA], [https://pdbe.org/7wai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wai RCSB], [https://www.ebi.ac.uk/pdbsum/7wai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wai ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8IDK7_PLAF7 Q8IDK7_PLAF7]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes in protein translation machinery that provide the charged tRNAs needed for protein synthesis. Over the past decades, aaRSs have been studied as anti-parasitic, anti-bacterial, and anti-fungal drug targets. This study focused on the cytoplasmic glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum, which belongs to class Ib in aaRSs. GluRS unlike most other aaRSs requires tRNA to activate its cognate amino acid substrate L-Glutamate (L-Glu), and fails to form an intermediate adenylate complex in the absence of tRNA. The crystal structures of the Apo, ATP, and ADP-bound forms of Plasmodium falciparum glutamyl-tRNA synthetase (PfGluRS) were solved at 2.1 A, 2.2 A, and 2.8 A respectively. The structural comparison of the Apo- and ATP-bound holo-forms of PfGluRS showed considerable conformational changes in the loop regions around the ATP-binding pocket of the enzyme. Biophysical characterization of the PfGluRS showed binding of the enzyme substrates L-Gluand ATP.. The sequence and structural conservation were evident across GluRS compared to other species. The structural dissection of the PfGluRS gives insight into the critical residues involved in the binding of ATP substrate, which can be harvested to develop new antimalarial drugs.

-	~~Authors~~:	+	Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.,Sharma VK, Chhibber-Goel J, Yogavel M, Sharma A Mol Biochem Parasitol. 2022 Nov 9;253:111530. doi: , 10.1016/j.molbiopara.2022.111530. PMID:36370911<ref>PMID:36370911</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7wai" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plasmodium falciparum 3D7]]
		+	[[Category: Harlos K]]
		+	[[Category: Manickam Y]]
		+	[[Category: Sharma A]]
		+	[[Category: Sharma V]]

OCA at 03:43, 26 October 2022

OCA — Wed, 26 Oct 2022 03:43:53 GMT

←Older revision		Revision as of 03:43, 26 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wai is ON HOLD until ~~Paper Publication~~	+	The entry 7wai is ON HOLD until 2024-06-14

	Authors:		Authors:

OCA at 05:40, 27 January 2022

OCA — Thu, 27 Jan 2022 05:40:06 GMT

←Older revision		Revision as of 05:40, 27 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wai is ON HOLD	+	The entry 7wai is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7wai" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:15:45 GMT

Protected "7wai" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:15, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7wai is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Dec 2021 14:15:43 GMT

New page: '''Unreleased structure''' The entry 7wai is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7wai is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]