7wf6 - Revision history

OCA at 17:40, 29 November 2023

OCA — Wed, 29 Nov 2023 17:40:22 GMT

←Older revision		Revision as of 17:40, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7wf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7wf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WF6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wf6 OCA], [https://pdbe.org/7wf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wf6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wf6 OCA], [https://pdbe.org/7wf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wf6 ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7wf6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7wf6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:06, 26 October 2022

OCA — Wed, 26 Oct 2022 06:06:18 GMT

←Older revision		Revision as of 06:06, 26 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wf6 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of SNX13 RGS domain==
		+	<StructureSection load='7wf6' size='340' side='right'caption='[[7wf6]], [[Resolution\|resolution]] 3.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7wf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WF6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wf6 OCA], [https://pdbe.org/7wf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wf6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SNX13_HUMAN SNX13_HUMAN] May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.<ref>PMID:11729322</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As a subgroup of sorting nexins (SNXs) that contain regulator of G protein signaling homology (RH) domain, SNX-RH proteins, including SNX13, SNX14 and SNX25, were proposed to play bifunctional roles in protein sorting and GPCR signaling regulation. However, mechanistic details of SNX-RH proteins functioning via RH domain remain to be illustrated. Here, we delineate crystal structures of the RH domains of SNX13 and SNX25, revealing a homodimer of SNX13 RH domain mediated by unique extended alpha4 and alpha5 helices, and a thiol modulated homodimer of SNX25-RH triggered by a unique cysteine on alpha6 helix. Further studies showed that RH domains of SNX-RH do not possess binding capacity toward Galpha subunits, owing to the lack of critical residues for interaction. Thus, this study identifies a group of novel non-canonical RH domains that can act as a dimerization module in sorting nexins, which provides structural basis for mechanism studies on SNX-RH protein functions.

-	~~Authors: Xu, J~~., ~~Zhu~~, J., Liu, J.	+	Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins.,Zhang Y, Chen R, Dong Y, Zhu J, Su K, Liu J, Xu J J Mol Biol. 2022 Sep 11;434(21):167823. doi: 10.1016/j.jmb.2022.167823. PMID:36103920<ref>PMID:36103920</ref>

-	~~Description: Crystal structure~~ of ~~SNX13 RGS domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Zhu,~~ J]]	+	<div class="pdbe-citations 7wf6" style="background-color:#fffaf0;"></div>
-	[[Category: Xu, J]]	+	== References ==
-	[[Category: ~~Liu,~~ J]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Liu J]]
		+	[[Category: Xu J]]
		+	[[Category: Zhu J]]

OCA at 09:15, 16 February 2022

OCA — Wed, 16 Feb 2022 09:15:11 GMT

←Older revision		Revision as of 09:15, 16 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wf6 is ON HOLD	+	The entry 7wf6 is ON HOLD until Paper Publication

	Authors: Xu, J., Zhu, J., Liu, J.		Authors: Xu, J., Zhu, J., Liu, J.
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	Description: Crystal structure of SNX13 RGS domain		Description: Crystal structure of SNX13 RGS domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Xu, J]]
	[[Category: Zhu, J]]		[[Category: Zhu, J]]
		+	[[Category: Xu, J]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA: Protected "7wf6" [edit=sysop:move=sysop]

OCA — Wed, 05 Jan 2022 09:25:48 GMT

Protected "7wf6" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:25, 5 January 2022

OCA: New page: '''Unreleased structure''' The entry 7wf6 is ON HOLD Authors: Xu, J., Zhu, J., Liu, J. Description: Crystal structure of SNX13 RGS domain Category: Unreleased Structures [[Category...

OCA — Wed, 05 Jan 2022 09:25:47 GMT

New page: '''Unreleased structure''' The entry 7wf6 is ON HOLD Authors: Xu, J., Zhu, J., Liu, J. Description: Crystal structure of SNX13 RGS domain Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 7wf6 is ON HOLD

Authors: Xu, J., Zhu, J., Liu, J.

Description: Crystal structure of SNX13 RGS domain
[[Category: Unreleased Structures]]
[[Category: Xu, J]]
[[Category: Zhu, J]]
[[Category: Liu, J]]