7wk0 - Revision history

OCA at 05:54, 8 September 2022

OCA — Thu, 08 Sep 2022 05:54:08 GMT

←Older revision		Revision as of 05:54, 8 September 2022
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-	====	+	==Local refine of Omicron spike bitrimer with 6m6 antibody==
-	<StructureSection load='7wk0' size='340' side='right'caption='[[7wk0]]' scene=''>	+	<StructureSection load='7wk0' size='340' side='right'caption='[[7wk0]], [[Resolution\|resolution]] 3.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7wk0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WK0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wk0 OCA], [https://pdbe.org/7wk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wk0 RCSB], [https://www.ebi.ac.uk/pdbsum/7wk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wk0 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wk0 OCA], [https://pdbe.org/7wk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wk0 RCSB], [https://www.ebi.ac.uk/pdbsum/7wk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wk0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Chen ZG]]
		+	[[Category: Sun L]]
		+	[[Category: Zhan WQ]]
		+	[[Category: Zhang X]]

OCA at 05:18, 13 July 2022

OCA — Wed, 13 Jul 2022 05:18:33 GMT

←Older revision		Revision as of 05:18, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wk0 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7wk0' size='340' side='right'caption='[[7wk0]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wk0 OCA], [https://pdbe.org/7wk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wk0 RCSB], [https://www.ebi.ac.uk/pdbsum/7wk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wk0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:38, 30 March 2022

OCA — Wed, 30 Mar 2022 09:38:14 GMT

←Older revision		Revision as of 09:38, 30 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wk0 is ON HOLD	+	The entry 7wk0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7wk0" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2022 06:09:24 GMT

Protected "7wk0" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:09, 19 January 2022

OCA: New page: '''Unreleased structure''' The entry 7wk0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jan 2022 06:09:23 GMT

New page: '''Unreleased structure''' The entry 7wk0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7wk0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]