7wkh - Revision history

OCA at 17:41, 29 November 2023

OCA — Wed, 29 Nov 2023 17:41:39 GMT

←Older revision		Revision as of 17:41, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7wkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ctenopharyngodon_idella Ctenopharyngodon idella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>		<table><tr><td colspan='2'>[[7wkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ctenopharyngodon_idella Ctenopharyngodon idella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkh OCA], [https://pdbe.org/7wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkh RCSB], [https://www.ebi.ac.uk/pdbsum/7wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkh OCA], [https://pdbe.org/7wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkh RCSB], [https://www.ebi.ac.uk/pdbsum/7wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2HZY8_CTEID Q2HZY8_CTEID]]	+	[https://www.uniprot.org/uniprot/Q2HZY8_CTEID Q2HZY8_CTEID]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 7wkh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7wkh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interferon 3D structures\|Interferon 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:05, 14 September 2022

OCA — Wed, 14 Sep 2022 07:05:34 GMT

←Older revision		Revision as of 07:05, 14 September 2022
Line 1:		Line 1:

	==the grass carp IFNa==		==the grass carp IFNa==
-	<StructureSection load='7wkh' size='340' side='right'caption='[[7wkh]]' scene=''>	+	<StructureSection load='7wkh' size='340' side='right'caption='[[7wkh]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7wkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ctenopharyngodon_idella Ctenopharyngodon idella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkh OCA], [https://pdbe.org/7wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkh RCSB], [https://www.ebi.ac.uk/pdbsum/7wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkh ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkh OCA], [https://pdbe.org/7wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkh RCSB], [https://www.ebi.ac.uk/pdbsum/7wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q2HZY8_CTEID Q2HZY8_CTEID]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Teleost type I interferons (IFNs) are categorized into group I and II subgroups that bind to distinct receptors to activate antiviral responses. However, the interaction between ifn ligands and receptors has not fully been understood. In this study, the crystal structure of grass carp [Ctenopharyngodon idella (Ci)] IFNa has been solved at 1.58A and consists of six helices. The CiIFNa displays a typical structure of type I IFNs with a straight helix F and lacks a helix element in the AB loop. Superposition modeling identified several key residues involved in the interaction with receptors. It was found that CiIFNa bound to cytokine receptor family B (CRFB) 1, CRFB2, and CRFB5, and the three receptors could form heterodimeric receptor complexes. Furthermore, mutation of Leu27, Glu103, Lys117, and His165 markedly decreased the phosphorylation of signal transducer and activator of transcription (STAT) 1a induced by CiIFNa in the Epithelioma papulosum cyprini (EPC) cells, and Glu103 was shown to be required for the CiIFNa-activated antiviral activity. Interestingly, wild-type and mutant CiIFNa proteins did not alter the phosphorylation levels of STAT1b. Our results demonstrate that fish type I IFNs, although structurally conserved, interact with the receptors in a manner that may differ from mammalian homologs.
		+
		+	Structural and Functional Analyses of Type I IFNa Shed Light Into Its Interaction With Multiple Receptors in Fish.,Wang Z, Xu J, Feng J, Wu K, Chen K, Jia Z, Zhu X, Huang W, Zhao X, Liu Q, Wang B, Chen X, Wang J, Zou J Front Immunol. 2022 Mar 22;13:862764. doi: 10.3389/fimmu.2022.862764. eCollection, 2022. PMID:35392096<ref>PMID:35392096</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7wkh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ctenopharyngodon idella]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: WANG J]]		[[Category: WANG J]]
	[[Category: Wang Z]]		[[Category: Wang Z]]
	[[Category: Zou J]]		[[Category: Zou J]]

OCA at 07:05, 2 February 2022

OCA — Wed, 02 Feb 2022 07:05:40 GMT

←Older revision		Revision as of 07:05, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wkh ~~is ON HOLD~~	+	==the grass carp IFNa==
-		+	<StructureSection load='7wkh' size='340' side='right'caption='[[7wkh]]' scene=''>
-	~~Authors~~: ~~Zou~~, J., ~~WANG~~, J., ~~Wang~~, Z.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>
-	~~Description: the grass carp IFNa~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkh OCA], [https://pdbe.org/7wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkh RCSB], [https://www.ebi.ac.uk/pdbsum/7wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkh ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zou,~~ J]]	+	__TOC__
-	[[Category: Wang, Z]]	+	</StructureSection>
-	[[Category: ~~Wang,~~ J]]	+	[[Category: Large Structures]]
		+	[[Category: WANG J]]
		+	[[Category: Wang Z]]
		+	[[Category: Zou J]]

OCA at 05:43, 27 January 2022

OCA — Thu, 27 Jan 2022 05:43:42 GMT

←Older revision		Revision as of 05:43, 27 January 2022
Line 3:		Line 3:
	The entry 7wkh is ON HOLD		The entry 7wkh is ON HOLD

-	Authors: ~~Jun~~, Z., ~~Junya~~, W., ~~Zixuan~~, W.	+	Authors: Zou, J., WANG, J., Wang, Z.

	Description: the grass carp IFNa		Description: the grass carp IFNa
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Zixuan~~, W]]	+	[[Category: Zou, J]]
-	[[Category: ~~Jun~~, Z]]	+	[[Category: Wang, Z]]
-	[[Category: ~~Junya~~, W]]	+	[[Category: Wang, J]]

OCA: Protected "7wkh" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2022 06:10:44 GMT

Protected "7wkh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:10, 19 January 2022

OCA: New page: '''Unreleased structure''' The entry 7wkh is ON HOLD Authors: Jun, Z., Junya, W., Zixuan, W. Description: the grass carp IFNa Category: Unreleased Structures [[Category: Zixuan, W]...

OCA — Wed, 19 Jan 2022 06:10:43 GMT

New page: '''Unreleased structure''' The entry 7wkh is ON HOLD Authors: Jun, Z., Junya, W., Zixuan, W. Description: the grass carp IFNa Category: Unreleased Structures [[Category: Zixuan, W]...

New page

'''Unreleased structure'''

The entry 7wkh is ON HOLD

Authors: Jun, Z., Junya, W., Zixuan, W.

Description: the grass carp IFNa
[[Category: Unreleased Structures]]
[[Category: Zixuan, W]]
[[Category: Jun, Z]]
[[Category: Junya, W]]