7wu8 - Revision history

OCA at 05:20, 9 August 2023

OCA — Wed, 09 Aug 2023 05:20:51 GMT

←Older revision		Revision as of 05:20, 9 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7wu8 is ~~ON HOLD until 2024~~-~~08-07~~	+	==Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1==
-		+	<StructureSection load='7wu8' size='340' side='right'caption='[[7wu8]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Kumar~~, N., ~~Rothweiler~~, U., ~~Singh~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7wu8]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WU8 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~Harmonin~~-~~homology domain 2~~ (~~HHD2~~) of ~~human RTEL1~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.599Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wu8 OCA], [https://pdbe.org/7wu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wu8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wu8 ProSAT]</span></td></tr>
-	[[Category: Kumar, N]]	+	</table>
-	[[Category: Rothweiler, U]]	+	== Disease ==
-	[[Category: Singh, M]]	+	[https://www.uniprot.org/uniprot/RTEL1_HUMAN RTEL1_HUMAN] Hoyeraal-Hreidarsson syndrome;Dyskeratosis congenita;Idiopathic pulmonary fibrosis. The disease is caused by variants affecting the gene represented in this entry. RTEL1 mutations have also been found in patients with a dyskeratosis congenita-like phenotype consisting of one feature of dyskeratosis congenita and short telomeres, in the absence of the typical DKC diagnostic triad (PubMed:23329068).<ref>PMID:23329068</ref> The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RTEL1_HUMAN RTEL1_HUMAN] ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.[HAMAP-Rule:MF_03065]<ref>PMID:18957201</ref> <ref>PMID:23453664</ref> <ref>PMID:24009516</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Kumar N]]
		+	[[Category: Rothweiler U]]
		+	[[Category: Singh M]]

OCA at 04:44, 25 January 2023

OCA — Wed, 25 Jan 2023 04:44:33 GMT

←Older revision		Revision as of 04:44, 25 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wu8 is ON HOLD until ~~Paper Publication~~	+	The entry 7wu8 is ON HOLD until 2024-08-07

	Authors: Kumar, N., Rothweiler, U., Singh, M.		Authors: Kumar, N., Rothweiler, U., Singh, M.
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	Description: Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1		Description: Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Rothweiler, U]]
	[[Category: Kumar, N]]		[[Category: Kumar, N]]
		+	[[Category: Rothweiler, U]]
	[[Category: Singh, M]]		[[Category: Singh, M]]

OCA at 05:02, 9 March 2022

OCA — Wed, 09 Mar 2022 05:02:31 GMT

←Older revision		Revision as of 05:02, 9 March 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wu8 is ON HOLD	+	The entry 7wu8 is ON HOLD until Paper Publication

	Authors: Kumar, N., Rothweiler, U., Singh, M.		Authors: Kumar, N., Rothweiler, U., Singh, M.

OCA: Protected "7wu8" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:20:07 GMT

Protected "7wu8" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:20, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7wu8 is ON HOLD Authors: Kumar, N., Rothweiler, U., Singh, M. Description: Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1 [[...

OCA — Wed, 16 Feb 2022 09:20:06 GMT

New page: '''Unreleased structure''' The entry 7wu8 is ON HOLD Authors: Kumar, N., Rothweiler, U., Singh, M. Description: Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1 [[...

New page

'''Unreleased structure'''

The entry 7wu8 is ON HOLD

Authors: Kumar, N., Rothweiler, U., Singh, M.

Description: Crystal structure of Harmonin-homology domain 2 (HHD2) of human RTEL1
[[Category: Unreleased Structures]]
[[Category: Rothweiler, U]]
[[Category: Kumar, N]]
[[Category: Singh, M]]