7wv5 - Revision history

OCA at 20:07, 16 November 2022

OCA — Wed, 16 Nov 2022 20:07:44 GMT

←Older revision		Revision as of 20:07, 16 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wv5 is ~~ON HOLD until Paper Publication~~	+	==ectoTLR3-poly(I:C)==
-		+	<StructureSection load='7wv5' size='340' side='right'caption='[[7wv5]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7wv5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WV5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wv5 OCA], [https://pdbe.org/7wv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wv5 RCSB], [https://www.ebi.ac.uk/pdbsum/7wv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wv5 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN] Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:[https://omim.org/entry/613002 613002]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.<ref>PMID:17872438</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:16144834</ref> <ref>PMID:16858407</ref> <ref>PMID:16720699</ref> <ref>PMID:17178723</ref> <ref>PMID:18172197</ref> <ref>PMID:16043704</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Han GM]]
		+	[[Category: Jang YH]]
		+	[[Category: Lee GY]]
		+	[[Category: Lee JO]]
		+	[[Category: Lim CS]]

OCA at 01:39, 21 April 2022

OCA — Thu, 21 Apr 2022 01:39:36 GMT

←Older revision		Revision as of 01:39, 21 April 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wv5 is ON HOLD	+	The entry 7wv5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:38, 23 February 2022

OCA — Wed, 23 Feb 2022 06:38:45 GMT

←Older revision		Revision as of 06:38, 23 February 2022
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	The entry 7wv5 is ON HOLD		The entry 7wv5 is ON HOLD

-	Authors: ~~Lim, C.S., Jang, Y.H., Lee, G.Y., Han, G.M., Lee, J.O.~~	+	Authors:

-	Description: ~~Toll-like receptor3 ectodomain dimeric form~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lee, J.O]]
-	[[Category: Han, G.M]]
-	[[Category: Lee, G.Y]]
-	[[Category: Lim, C.S]]
-	[[Category: Jang, Y.H]]

OCA: Protected "7wv5" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:21:37 GMT

Protected "7wv5" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:21, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7wv5 is ON HOLD Authors: Lim, C.S., Jang, Y.H., Lee, G.Y., Han, G.M., Lee, J.O. Description: Toll-like receptor3 ectodomain dimeric form [[Category...

OCA — Wed, 16 Feb 2022 09:21:36 GMT

New page: '''Unreleased structure''' The entry 7wv5 is ON HOLD Authors: Lim, C.S., Jang, Y.H., Lee, G.Y., Han, G.M., Lee, J.O. Description: Toll-like receptor3 ectodomain dimeric form [[Category...

New page

'''Unreleased structure'''

The entry 7wv5 is ON HOLD

Authors: Lim, C.S., Jang, Y.H., Lee, G.Y., Han, G.M., Lee, J.O.

Description: Toll-like receptor3 ectodomain dimeric form
[[Category: Unreleased Structures]]
[[Category: Lee, J.O]]
[[Category: Han, G.M]]
[[Category: Lee, G.Y]]
[[Category: Lim, C.S]]
[[Category: Jang, Y.H]]