7x66 - Revision history

OCA at 17:48, 29 November 2023

OCA — Wed, 29 Nov 2023 17:48:30 GMT

←Older revision		Revision as of 17:48, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7x66]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7x66]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X66 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x66 OCA], [https://pdbe.org/7x66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x66 RCSB], [https://www.ebi.ac.uk/pdbsum/7x66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x66 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x66 OCA], [https://pdbe.org/7x66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x66 RCSB], [https://www.ebi.ac.uk/pdbsum/7x66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x66 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:28, 8 March 2023

OCA — Wed, 08 Mar 2023 07:28:21 GMT

←Older revision		Revision as of 07:28, 8 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7x66 ~~is ON HOLD until Paper Publication~~	+	==SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex==
-		+	<StructureSection load='7x66' size='340' side='right'caption='[[7x66]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Shi~~, R., ~~Wang~~, Y., Wu, Z., ~~Han, X~~., ~~Yan~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7x66]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X66 FirstGlance]. <br>
-	~~Description~~: ~~SARS~~-~~CoV~~-2-~~Omicron~~-~~RBD~~ and BD-~~236~~-~~GWP/P~~-~~VK antibody complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x66 OCA], [https://pdbe.org/7x66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x66 RCSB], [https://www.ebi.ac.uk/pdbsum/7x66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x66 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Yan, J~~]]	+	== Function ==
-	[[Category: ~~Wu, Z~~]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: Shi, R]]	+	== References ==
-	[[Category: Wang, Y]]	+	<references/>
-	[[Category: ~~Han, X~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Han X]]
		+	[[Category: Shi R]]
		+	[[Category: Wang Y]]
		+	[[Category: Wu Z]]
		+	[[Category: Yan J]]

OCA at 06:42, 25 May 2022

OCA — Wed, 25 May 2022 06:42:56 GMT

←Older revision		Revision as of 06:42, 25 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7x66 is ON HOLD	+	The entry 7x66 is ON HOLD until Paper Publication

	Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.		Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.

OCA at 09:08, 18 May 2022

OCA — Wed, 18 May 2022 09:08:24 GMT

←Older revision		Revision as of 09:08, 18 May 2022
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	Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.		Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.

-	Description: BD-236 ~~against omicron variant~~	+	Description: SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yan, J]]		[[Category: Yan, J]]

OCA at 01:40, 21 April 2022

OCA — Thu, 21 Apr 2022 01:40:12 GMT

←Older revision		Revision as of 01:40, 21 April 2022
Line 5:		Line 5:
	Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.		Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.

-	Description: ~~An Andibody~~ against ~~SA varient~~	+	Description: BD-236 against omicron variant
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Yan, J]]
	[[Category: Wu, Z]]		[[Category: Wu, Z]]
	[[Category: Shi, R]]		[[Category: Shi, R]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]
-	[[Category: Yan, J]]
	[[Category: Han, X]]		[[Category: Han, X]]

OCA: Protected "7x66" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2022 05:12:11 GMT

Protected "7x66" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 16 March 2022

OCA: New page: '''Unreleased structure''' The entry 7x66 is ON HOLD Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. Description: An Andibody against SA varient [[Category: Unreleased Structures]...

OCA — Wed, 16 Mar 2022 05:12:10 GMT

New page: '''Unreleased structure''' The entry 7x66 is ON HOLD Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. Description: An Andibody against SA varient [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 7x66 is ON HOLD

Authors: Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J.

Description: An Andibody against SA varient
[[Category: Unreleased Structures]]
[[Category: Wu, Z]]
[[Category: Shi, R]]
[[Category: Wang, Y]]
[[Category: Yan, J]]
[[Category: Han, X]]