7xfp - Revision history

OCA at 19:45, 29 May 2024

OCA — Wed, 29 May 2024 19:45:56 GMT

←Older revision		Revision as of 19:45, 29 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7xfp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7xfp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xfp OCA], [https://pdbe.org/7xfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xfp RCSB], [https://www.ebi.ac.uk/pdbsum/7xfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xfp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xfp OCA], [https://pdbe.org/7xfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xfp RCSB], [https://www.ebi.ac.uk/pdbsum/7xfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xfp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:24, 21 December 2022

OCA — Wed, 21 Dec 2022 09:24:41 GMT

←Older revision		Revision as of 09:24, 21 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7xfp is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Helicobacter pylori IceA2==
		+	<StructureSection load='7xfp' size='340' side='right'caption='[[7xfp]], [[Resolution\|resolution]] 1.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7xfp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XFP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xfp OCA], [https://pdbe.org/7xfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xfp RCSB], [https://www.ebi.ac.uk/pdbsum/7xfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xfp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0B2EID0_HELPX A0A0B2EID0_HELPX]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Helicobacter pylori is a pathogenic bacterium that causes gastric ulcers and cancer. Among the diverse virulence genes of H. pylori, the IceA gene was identified to be expressed upon adherence to host cells. The IceA gene has two alleles, iceA1 and iceA2, which encode completely different proteins. IceA1 protein was shown to exert endonuclease activity, whereas IceA2 has never been analyzed at the molecular level. Based on a sequence analysis, IceA2 proteins differ in length depending on the strain and are classified into five groups (A-E). To structurally characterize IceA2, we determined the crystal structure of group-D IceA2 (IceA2(sD)) and performed a modeling-based comparative analysis of IceA2 groups. IceA2(sD) consists of three beta-sheet repeats and serially arranges them like the beta-propeller structure of the WD40 domain. However, each beta-sheet of IceA2 is stabilized using a unique structural motif that is not observed in WD40. Moreover, IceA2(sD) lacks an additionally appended beta-strand and does not form the Velcro-like closure of WD40. Therefore, IceA2(sD) adopts a curved rod-like structure rather than an enclosed circular structure in WD40. IceA2 proteins contain 1-4 beta-sheet modules depending on the groups and are modeled to be highly diverse in size and shape.

-	~~Authors~~:	+	Structural analysis of the virulence gene protein IceA2 from Helicobacter pylori.,Cho HY, Cho H, Song WS, Yoon SI Biochem Biophys Res Commun. 2022 Jul 5;612:162-168. doi: , 10.1016/j.bbrc.2022.04.090. Epub 2022 Apr 25. PMID:35526497<ref>PMID:35526497</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7xfp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Large Structures]]
		+	[[Category: Cho HY]]
		+	[[Category: Song WS]]
		+	[[Category: Yoon SI]]

OCA at 01:41, 21 April 2022

OCA — Thu, 21 Apr 2022 01:41:40 GMT

←Older revision		Revision as of 01:41, 21 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xfp is ON HOLD	+	The entry 7xfp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xfp" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2022 08:41:40 GMT

Protected "7xfp" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:41, 13 April 2022

OCA: New page: '''Unreleased structure''' The entry 7xfp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Apr 2022 08:41:39 GMT

New page: '''Unreleased structure''' The entry 7xfp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xfp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]