OCA at 10:41, 30 November 2022

OCA — Wed, 30 Nov 2022 10:41:02 GMT

←Older revision		Revision as of 10:41, 30 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7xi9 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form)==
-		+	<StructureSection load='7xi9' size='340' side='right'caption='[[7xi9]], [[Resolution\|resolution]] 2.52Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xi9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XI9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=EIX:[(2R,3S,5S)-5-[(4R,5R)-6-azanyl-5-fluoranyl-5-methyl-2-oxidanylidene-4-sulfanyl-4H-pyrimidin-3-yl]-3-oxidanyl-oxolan-2-yl]methyl+dihydrogen+phosphate'>EIX</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xi9 OCA], [https://pdbe.org/7xi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xi9 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN] Defects in DNMT1 are the cause of hereditary sensory neuropathy type 1E (HSN1E) [MIM:[https://omim.org/entry/614116 614116]. A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.<ref>PMID:21532572</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:16357870</ref> <ref>PMID:18754681</ref> <ref>PMID:18413740</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Arita K]]
		+	[[Category: Kikuchi A]]
		+	[[Category: Kori S]]
		+	[[Category: Onoda H]]
		+	[[Category: Yamagata A]]
		+	[[Category: Yoshimi S]]

OCA at 11:39, 4 May 2022

OCA — Wed, 04 May 2022 11:39:39 GMT

←Older revision		Revision as of 11:39, 4 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xi9 is ON HOLD	+	The entry 7xi9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xi9" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:43:28 GMT

Protected "7xi9" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:43, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7xi9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 21 Apr 2022 01:43:28 GMT

New page: '''Unreleased structure''' The entry 7xi9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xi9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7xi9 - Revision history

OCA at 10:41, 30 November 2022

OCA at 11:39, 4 May 2022

OCA: Protected "7xi9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7xi9 is ON HOLD Authors: Description: Category: Unreleased Structures