OCA at 09:04, 30 August 2023

OCA — Wed, 30 Aug 2023 09:04:59 GMT

←Older revision		Revision as of 09:04, 30 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7xl8 is ~~ON HOLD until Paper~~ Publication	+	==Human Cx36/GJD2 (N-terminal deletion mutant) gap junction channel in soybean lipids (D6 symmetry)==
		+	<StructureSection load='7xl8' size='340' side='right'caption='[[7xl8]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7xl8]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XL8 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xl8 OCA], [https://pdbe.org/7xl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xl8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CXD2_HUMAN CXD2_HUMAN] One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Connexin 36 (Cx36) is responsible for signal transmission in electrical synapses by forming interneuronal gap junctions. Despite the critical role of Cx36 in normal brain function, the molecular architecture of the Cx36 gap junction channel (GJC) is unknown. Here, we determine cryo-electron microscopy structures of Cx36 GJC at 2.2-3.6 A resolutions, revealing a dynamic equilibrium between its closed and open states. In the closed state, channel pores are obstructed by lipids, while N-terminal helices (NTHs) are excluded from the pore. In the open state with pore-lining NTHs, the pore is more acidic than those in Cx26 and Cx46/50 GJCs, explaining its strong cation selectivity. The conformational change during channel opening also includes the alpha-to-pi-helix transition of the first transmembrane helix, which weakens the protomer-protomer interaction. Our structural analyses provide high resolution information on the conformational flexibility of Cx36 GJC and suggest a potential role of lipids in the channel gating.

-	~~Authors~~:	+	Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.,Lee SN, Cho HJ, Jeong H, Ryu B, Lee HJ, Kim M, Yoo J, Woo JS, Lee HH Nat Commun. 2023 Mar 11;14(1):1347. doi: 10.1038/s41467-023-37040-8. PMID:36906653<ref>PMID:36906653</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7xl8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cho HJ]]
		+	[[Category: Jeong H]]
		+	[[Category: Lee HH]]
		+	[[Category: Lee HJ]]
		+	[[Category: Lee SN]]
		+	[[Category: Ryu B]]
		+	[[Category: Woo JS]]

OCA at 03:46, 9 August 2023

OCA — Wed, 09 Aug 2023 03:46:21 GMT

←Older revision		Revision as of 03:46, 9 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xl8 is ON HOLD	+	The entry 7xl8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xl8" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2022 10:36:16 GMT

Protected "7xl8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:36, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7xl8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Apr 2022 10:36:15 GMT

New page: '''Unreleased structure''' The entry 7xl8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xl8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7xl8 - Revision history

OCA at 09:04, 30 August 2023

OCA at 03:46, 9 August 2023

OCA: Protected "7xl8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7xl8 is ON HOLD Authors: Description: Category: Unreleased Structures