OCA at 06:43, 8 February 2023

OCA — Wed, 08 Feb 2023 06:43:16 GMT

←Older revision		Revision as of 06:43, 8 February 2023
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-	'''Unreleased structure'''

-	The entry ~~7xlq~~ is ~~ON HOLD~~	+	==Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state==
		+	<StructureSection load='7xlq' size='340' side='right'caption='[[7xlq]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7xlq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XLQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xlq OCA], [https://pdbe.org/7xlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xlq RCSB], [https://www.ebi.ac.uk/pdbsum/7xlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xlq ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAC1E_HUMAN CAC1E_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAC1E_HUMAN CAC1E_HUMAN] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.<ref>PMID:30343943</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-voltage-activated R-type Ca(V)2.3 channel plays pivotal roles in many physiological activities and is implicated in epilepsy, convulsions, and other neurodevelopmental impairments. Here, we determine the high-resolution cryo-electron microscopy (cryo-EM) structure of human Ca(V)2.3 in complex with the alpha2delta1 and beta1 subunits. The VSD(II) is stabilized in the resting state. Electrophysiological experiments elucidate that the VSD(II) is not required for channel activation, whereas the other VSDs are essential for channel opening. The intracellular gate is blocked by the W-helix. A pre-W-helix adjacent to the W-helix can significantly regulate closed-state inactivation (CSI) by modulating the association and dissociation of the W-helix with the gate. Electrostatic interactions formed between the negatively charged domain on S6(II), which is exclusively conserved in the Ca(V)2 family, and nearby regions at the alpha-interacting domain (AID) and S4-S5(II) helix are identified. Further functional analyses indicate that these interactions are critical for the open-state inactivation (OSI) of Ca(V)2 channels.

-	~~Authors~~:	+	Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3.,Gao Y, Xu S, Cui X, Xu H, Qiu Y, Wei Y, Dong Y, Zhu B, Peng C, Liu S, Zhang XC, Sun J, Huang Z, Zhao Y Nat Commun. 2023 Jan 31;14(1):516. doi: 10.1038/s41467-023-36260-2. PMID:36720859<ref>PMID:36720859</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7xlq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Dong Y]]
		+	[[Category: Gao Y]]
		+	[[Category: Qiu Y]]
		+	[[Category: Wei Y]]
		+	[[Category: Zhang XC]]
		+	[[Category: Zhao Y]]

OCA: Protected "7xlq" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2022 10:37:00 GMT

Protected "7xlq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:37, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7xlq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Apr 2022 10:36:59 GMT

New page: '''Unreleased structure''' The entry 7xlq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xlq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7xlq - Revision history

OCA at 06:43, 8 February 2023

OCA: Protected "7xlq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7xlq is ON HOLD Authors: Description: Category: Unreleased Structures