7xmp - Revision history

OCA at 17:56, 29 November 2023

OCA — Wed, 29 Nov 2023 17:56:22 GMT

←Older revision		Revision as of 17:56, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7xmp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7xmp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XMP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xmp OCA], [https://pdbe.org/7xmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xmp RCSB], [https://www.ebi.ac.uk/pdbsum/7xmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xmp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.27Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xmp OCA], [https://pdbe.org/7xmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xmp RCSB], [https://www.ebi.ac.uk/pdbsum/7xmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xmp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.<ref>PMID:9052782</ref> <ref>PMID:11821063</ref> <ref>PMID:12354387</ref>		[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.<ref>PMID:9052782</ref> <ref>PMID:11821063</ref> <ref>PMID:12354387</ref>
		+
		+	==See Also==
		+	*[[LDL receptor\|LDL receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:25, 3 May 2023

OCA — Wed, 03 May 2023 07:25:36 GMT

←Older revision		Revision as of 07:25, 3 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7xmp is ~~ON HOLD until Paper Publication~~	+	==High resolution structure of lectin-like Ox-LDL receptor 1 in space group P 32 2 1==
-		+	<StructureSection load='7xmp' size='340' side='right'caption='[[7xmp]], [[Resolution\|resolution]] 1.27Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xmp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XMP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xmp OCA], [https://pdbe.org/7xmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xmp RCSB], [https://www.ebi.ac.uk/pdbsum/7xmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xmp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.<ref>PMID:12384789</ref> <ref>PMID:12807963</ref> <ref>PMID:15060104</ref> <ref>PMID:15276231</ref> <ref>PMID:15860461</ref> Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.<ref>PMID:12384789</ref> <ref>PMID:12807963</ref> <ref>PMID:15060104</ref> <ref>PMID:15276231</ref> <ref>PMID:15860461</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN] Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.<ref>PMID:9052782</ref> <ref>PMID:11821063</ref> <ref>PMID:12354387</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Arockiasamy A]]
		+	[[Category: Tomar A]]
		+	[[Category: Varughese KI]]

OCA at 03:54, 15 June 2022

OCA — Wed, 15 Jun 2022 03:54:22 GMT

←Older revision		Revision as of 03:54, 15 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xmp is ON HOLD	+	The entry 7xmp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xmp" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2022 11:41:56 GMT

Protected "7xmp" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:41, 4 May 2022

OCA: New page: '''Unreleased structure''' The entry 7xmp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 May 2022 11:41:55 GMT

New page: '''Unreleased structure''' The entry 7xmp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xmp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]