7xou - Revision history

OCA at 05:03, 8 September 2022

OCA — Thu, 08 Sep 2022 05:03:10 GMT

←Older revision		Revision as of 05:03, 8 September 2022
Line 1:		Line 1:

-	====	+	==Structural insights into human brain gut peptide cholecystokinin receptors==
-	<StructureSection load='7xou' size='340' side='right'caption='[[7xou]]' scene=''>	+	<StructureSection load='7xou' size='340' side='right'caption='[[7xou]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7xou]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xou OCA], [https://pdbe.org/7xou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xou RCSB], [https://www.ebi.ac.uk/pdbsum/7xou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xou ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xou OCA], [https://pdbe.org/7xou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xou RCSB], [https://www.ebi.ac.uk/pdbsum/7xou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xou ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN]] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Chen L]]
		+	[[Category: Ding Y]]
		+	[[Category: Ji S]]
		+	[[Category: Liao Y]]
		+	[[Category: Zhang H]]

OCA at 06:56, 20 July 2022

OCA — Wed, 20 Jul 2022 06:56:05 GMT

←Older revision		Revision as of 06:56, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7xou ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7xou' size='340' side='right'caption='[[7xou]]' scene=''>
-	~~Authors~~: ~~Ding, Y~~.~~, Zhang, H~~.~~, Liao, Y~~.~~, Chen, L~~.~~, Ji, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structural insights into human brain gut peptide cholecystokinin receptors~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xou OCA], [https://pdbe.org/7xou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xou RCSB], [https://www.ebi.ac.uk/pdbsum/7xou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xou ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Zhang, H~~]]	+	__TOC__
-	[~~[Category~~: Ji, S]]	+	</StructureSection>
-	[~~[Category~~: ~~Ding~~, Y]]	+	[[Category: Large Structures]]
-	[[Category: ~~Liao, Y~~]]	+	[[Category: Z-disk]]
-	[[Category: ~~Chen, L~~]]	+

OCA at 07:00, 22 June 2022

OCA — Wed, 22 Jun 2022 07:00:16 GMT

←Older revision		Revision as of 07:00, 22 June 2022
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
		+	[[Category: Ji, S]]
	[[Category: Ding, Y]]		[[Category: Ding, Y]]
	[[Category: Liao, Y]]		[[Category: Liao, Y]]
-	[[Category: Ji, S]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA: Protected "7xou" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2022 04:57:23 GMT

Protected "7xou" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 12 May 2022

OCA: New page: '''Unreleased structure''' The entry 7xou is ON HOLD Authors: Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. Description: Structural insights into human brain gut peptide cholecystoki...

OCA — Thu, 12 May 2022 04:57:22 GMT

New page: '''Unreleased structure''' The entry 7xou is ON HOLD Authors: Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. Description: Structural insights into human brain gut peptide cholecystoki...

New page

'''Unreleased structure'''

The entry 7xou is ON HOLD

Authors: Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S.

Description: Structural insights into human brain gut peptide cholecystokinin receptors
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Ding, Y]]
[[Category: Liao, Y]]
[[Category: Ji, S]]
[[Category: Chen, L]]