7xoy - Revision history

OCA at 08:33, 7 December 2022

OCA — Wed, 07 Dec 2022 08:33:19 GMT

←Older revision		Revision as of 08:33, 7 December 2022
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	==Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine and serine.==		==Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine and serine.==
-	<StructureSection load='7xoy' size='340' side='right'caption='[[7xoy]]' scene=''>	+	<StructureSection load='7xoy' size='340' side='right'caption='[[7xoy]], [[Resolution\|resolution]] 4.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7xoy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xoy OCA], [https://pdbe.org/7xoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xoy RCSB], [https://www.ebi.ac.uk/pdbsum/7xoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xoy ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLS:[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE'>PLS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xoy OCA], [https://pdbe.org/7xoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xoy RCSB], [https://www.ebi.ac.uk/pdbsum/7xoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xoy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y1077_MYCTU Y1077_MYCTU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between antioxidant and methylation metabolism in diverse organisms. Using a combination of biochemistry and cryo-electron microscopy, we characterized the first enzyme of the transsulfuration pathway, cystathionine beta-synthase (MtbCbs) in Mtb. We demonstrated that MtbCbs is a heme-less, pyridoxal-5'-phosphate-containing enzyme, allosterically activated by S-adenosylmethionine (SAM). The atomic model of MtbCbs in its native and SAM-bound conformations revealed a unique mode of SAM-dependent allosteric activation. Further, SAM stabilized MtbCbs by sterically occluding proteasomal degradation, which was crucial for supporting methionine and redox metabolism in Mtb. Genetic deficiency of MtbCbs reduced Mtb survival upon homocysteine overload in vitro, inside macrophages, and in mice coinfected with HIV. Thus, the MtbCbs-SAM axis constitutes an important mechanism of coordinating sulfur metabolism in Mtb.
		+
		+	S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.,Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, Rajmani RS, Laxman S, Dutta S, Singh A Sci Adv. 2022 Jun 24;8(25):eabo0097. doi: 10.1126/sciadv.abo0097. Epub 2022 Jun , 24. PMID:35749503<ref>PMID:35749503</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7xoy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Bandyopadhyay P]]		[[Category: Bandyopadhyay P]]
	[[Category: Biswas R]]		[[Category: Biswas R]]

OCA at 08:00, 25 May 2022

OCA — Wed, 25 May 2022 08:00:45 GMT

←Older revision		Revision as of 08:00, 25 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7xoy is ~~ON HOLD until Paper Publication~~	+	==Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine and serine.==
-		+	<StructureSection load='7xoy' size='340' side='right'caption='[[7xoy]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xoy OCA], [https://pdbe.org/7xoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xoy RCSB], [https://www.ebi.ac.uk/pdbsum/7xoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xoy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bandyopadhyay P]]
		+	[[Category: Biswas R]]
		+	[[Category: Dutta S]]
		+	[[Category: Laxman S]]
		+	[[Category: Pramanick I]]
		+	[[Category: Rajmani R]]
		+	[[Category: Sabarinath PS]]
		+	[[Category: Singh A]]
		+	[[Category: Singh S]]
		+	[[Category: Sreedharan S]]

OCA at 09:10, 18 May 2022

OCA — Wed, 18 May 2022 09:10:29 GMT

←Older revision		Revision as of 09:10, 18 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xoy is ON HOLD	+	The entry 7xoy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xoy" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2022 04:57:36 GMT

Protected "7xoy" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 12 May 2022

OCA: New page: '''Unreleased structure''' The entry 7xoy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 12 May 2022 04:57:35 GMT

New page: '''Unreleased structure''' The entry 7xoy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xoy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]