OCA at 13:48, 29 November 2023

OCA — Wed, 29 Nov 2023 13:48:47 GMT

←Older revision		Revision as of 13:48, 29 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7xuz is ~~ON HOLD until 2024~~-11-20	+	==Crystal structure of a HDAC4-MEF2A-DNA ternary complex==
-		+	<StructureSection load='7xuz' size='340' side='right'caption='[[7xuz]], [[Resolution\|resolution]] 3.59Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xuz]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XUZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.591Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xuz OCA], [https://pdbe.org/7xuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xuz RCSB], [https://www.ebi.ac.uk/pdbsum/7xuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xuz ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN] Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:[https://omim.org/entry/600430 600430]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.<ref>PMID:20691407</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.<ref>PMID:10523670</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bates D]]
		+	[[Category: Cayford J]]
		+	[[Category: Chen L]]
		+	[[Category: Chen XJ]]
		+	[[Category: Chen YH]]
		+	[[Category: Dai SY]]
		+	[[Category: Dey R]]
		+	[[Category: Guo L]]
		+	[[Category: Guo M]]
		+	[[Category: Wei XD]]

OCA at 14:45, 26 April 2023

OCA — Wed, 26 Apr 2023 14:45:11 GMT

←Older revision		Revision as of 14:45, 26 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xuz is ON HOLD until 2024-05-20	+	The entry 7xuz is ON HOLD until 2024-11-20

	Authors:		Authors:

OCA at 14:54, 6 July 2022

OCA — Wed, 06 Jul 2022 14:54:50 GMT

←Older revision		Revision as of 14:54, 6 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xuz is ON HOLD	+	The entry 7xuz is ON HOLD until 2024-05-20

	Authors:		Authors:

OCA: Protected "7xuz" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2022 06:49:45 GMT

Protected "7xuz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:49, 25 May 2022

OCA: New page: '''Unreleased structure''' The entry 7xuz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 May 2022 06:49:44 GMT

New page: '''Unreleased structure''' The entry 7xuz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xuz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7xuz - Revision history

OCA at 13:48, 29 November 2023

OCA at 14:45, 26 April 2023

OCA at 14:54, 6 July 2022

OCA: Protected "7xuz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7xuz is ON HOLD Authors: Description: Category: Unreleased Structures