7xvi - Revision history

OCA at 19:46, 29 May 2024

OCA — Wed, 29 May 2024 19:46:26 GMT

←Older revision		Revision as of 19:46, 29 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/A0A833T3B4_PHYIN A0A833T3B4_PHYIN]		[https://www.uniprot.org/uniprot/A0A833T3B4_PHYIN A0A833T3B4_PHYIN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pathogens produce diverse effector proteins to manipulate host cellular processes. However, how functional diversity is generated in an effector repertoire is poorly understood. Many effectors in the devastating plant pathogen Phytophthora contain tandem repeats of the "(L)WY" motif, which are structurally conserved but variable in sequences. Here, we discovered a functional module formed by a specific (L)WY-LWY combination in multiple Phytophthora effectors, which efficiently recruits the serine/threonine protein phosphatase 2A (PP2A) core enzyme in plant hosts. Crystal structure of an effector-PP2A complex shows that the (L)WY-LWY module enables hijacking of the host PP2A core enzyme to form functional holoenzymes. While sharing the PP2A-interacting module at the amino terminus, these effectors possess divergent C-terminal LWY units and regulate distinct sets of phosphoproteins in the host. Our results highlight the appropriation of an essential host phosphatase through molecular mimicry by pathogens and diversification promoted by protein modularity in an effector repertoire.
		+
		+	Pathogen protein modularity enables elaborate mimicry of a host phosphatase.,Li H, Wang J, Kuan TA, Tang B, Feng L, Wang J, Cheng Z, Sklenar J, Derbyshire P, Hulin M, Li Y, Zhai Y, Hou Y, Menke FLH, Wang Y, Ma W Cell. 2023 Jul 20;186(15):3196-3207.e17. doi: 10.1016/j.cell.2023.05.049. Epub , 2023 Jun 26. PMID:37369204<ref>PMID:37369204</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7xvi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:36, 5 July 2023

OCA — Wed, 05 Jul 2023 05:36:43 GMT

←Older revision		Revision as of 05:36, 5 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7xvi is ~~ON HOLD until 2024~~-08-02	+	==pathogen effectors which are essential to cause plant disease by manipulating cellular processes in the host==
-		+	<StructureSection load='7xvi' size='340' side='right'caption='[[7xvi]], [[Resolution\|resolution]] 3.11Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_infestans Phytophthora infestans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XVI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.11Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xvi OCA], [https://pdbe.org/7xvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xvi RCSB], [https://www.ebi.ac.uk/pdbsum/7xvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xvi ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A833T3B4_PHYIN A0A833T3B4_PHYIN]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Phytophthora infestans]]
		+	[[Category: Wang J]]
		+	[[Category: Wang Y]]

OCA at 04:09, 7 June 2023

OCA — Wed, 07 Jun 2023 04:09:05 GMT

←Older revision		Revision as of 04:09, 7 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xvi is ON HOLD until 2024-07-05	+	The entry 7xvi is ON HOLD until 2024-08-02

	Authors:		Authors:

OCA at 07:45, 19 April 2023

OCA — Wed, 19 Apr 2023 07:45:33 GMT

←Older revision		Revision as of 07:45, 19 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xvi is ON HOLD until ~~Paper Publication~~	+	The entry 7xvi is ON HOLD until 2024-07-05

	Authors:		Authors:

OCA at 07:02, 22 June 2022

OCA — Wed, 22 Jun 2022 07:02:20 GMT

←Older revision		Revision as of 07:02, 22 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xvi is ON HOLD	+	The entry 7xvi is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7xvi" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:00:44 GMT

Protected "7xvi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:00, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7xvi is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jun 2022 04:00:43 GMT

New page: '''Unreleased structure''' The entry 7xvi is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xvi is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]