7xwa - Revision history

OCA at 18:02, 29 November 2023

OCA — Wed, 29 Nov 2023 18:02:16 GMT

←Older revision		Revision as of 18:02, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7xwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7xwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.36Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xwa OCA], [https://pdbe.org/7xwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xwa RCSB], [https://www.ebi.ac.uk/pdbsum/7xwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xwa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xwa OCA], [https://pdbe.org/7xwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xwa RCSB], [https://www.ebi.ac.uk/pdbsum/7xwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xwa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 19:34, 19 October 2022

OCA — Wed, 19 Oct 2022 19:34:46 GMT

←Older revision		Revision as of 19:34, 19 October 2022
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	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>	+	[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:20, 28 September 2022

OCA — Wed, 28 Sep 2022 06:20:11 GMT

←Older revision		Revision as of 06:20, 28 September 2022
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-	'''Unreleased structure'''

-	~~The entry 7xwa is ON HOLD until Paper Publication~~	+	==Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2==
-		+	<StructureSection load='7xwa' size='340' side='right'caption='[[7xwa]], [[Resolution\|resolution]] 3.36Å' scene=''>
-	~~Authors: Suzuki, T., Kimura, K., Hashiguchi, T.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XWA FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xwa OCA], [https://pdbe.org/7xwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xwa RCSB], [https://www.ebi.ac.uk/pdbsum/7xwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xwa ProSAT]</span></td></tr>
-	[[Category: ~~Hashiguchi, T~~]]	+	</table>
-	[[Category: ~~Suzuki,~~ T]]	+	== Function ==
-	[[Category: Kimura, K]]	+	[[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Hashiguchi T]]
		+	[[Category: Kimura K]]
		+	[[Category: Suzuki T]]

OCA at 05:17, 31 August 2022

OCA — Wed, 31 Aug 2022 05:17:06 GMT

←Older revision		Revision as of 05:17, 31 August 2022
Line 5:		Line 5:
	Authors: Suzuki, T., Kimura, K., Hashiguchi, T.		Authors: Suzuki, T., Kimura, K., Hashiguchi, T.

-	Description: ~~Viral~~ protein complex	+	Description: Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Hashiguchi, T]]		[[Category: Hashiguchi, T]]
	[[Category: Suzuki, T]]		[[Category: Suzuki, T]]
	[[Category: Kimura, K]]		[[Category: Kimura, K]]

OCA at 03:56, 13 July 2022

OCA — Wed, 13 Jul 2022 03:56:18 GMT

←Older revision		Revision as of 03:56, 13 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xwa is ON HOLD	+	The entry 7xwa is ON HOLD until Paper Publication

	Authors: Suzuki, T., Kimura, K., Hashiguchi, T.		Authors: Suzuki, T., Kimura, K., Hashiguchi, T.

OCA: Protected "7xwa" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:02:07 GMT

Protected "7xwa" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:02, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7xwa is ON HOLD Authors: Suzuki, T., Kimura, K., Hashiguchi, T. Description: Viral protein complex Category: Unreleased Structures [[Category: ...

OCA — Wed, 08 Jun 2022 04:02:06 GMT

New page: '''Unreleased structure''' The entry 7xwa is ON HOLD Authors: Suzuki, T., Kimura, K., Hashiguchi, T. Description: Viral protein complex Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 7xwa is ON HOLD

Authors: Suzuki, T., Kimura, K., Hashiguchi, T.

Description: Viral protein complex
[[Category: Unreleased Structures]]
[[Category: Hashiguchi, T]]
[[Category: Suzuki, T]]
[[Category: Kimura, K]]