OCA at 07:58, 6 December 2023

OCA — Wed, 06 Dec 2023 07:58:48 GMT

←Older revision		Revision as of 07:58, 6 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7xyd is ~~ON HOLD until 2024~~-12-01	+	==Crystal structure of TMPRSS2 in complex with Nafamostat==
-		+	<StructureSection load='7xyd' size='340' side='right'caption='[[7xyd]], [[Resolution\|resolution]] 2.58Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7xyd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XYD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.58Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GBS:4-GUANIDINOBENZOIC+ACID'>GBS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xyd OCA], [https://pdbe.org/7xyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xyd RCSB], [https://www.ebi.ac.uk/pdbsum/7xyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xyd ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TMPS2_HUMAN TMPS2_HUMAN] Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).[UniProtKB:Q9JIQ8]<ref>PMID:15537383</ref> <ref>PMID:25122198</ref> <ref>PMID:26018085</ref> (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.<ref>PMID:21068237</ref> <ref>PMID:21325420</ref> <ref>PMID:23536651</ref> <ref>PMID:23966399</ref> <ref>PMID:24027332</ref> <ref>PMID:24227843</ref> <ref>PMID:32142651</ref> <ref>PMID:32404436</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Duan Y]]
		+	[[Category: Liu X]]
		+	[[Category: Sun L]]
		+	[[Category: Wang H]]
		+	[[Category: Yang H]]

OCA at 05:44, 25 October 2023

OCA — Wed, 25 Oct 2023 05:44:51 GMT

←Older revision		Revision as of 05:44, 25 October 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7xyd is ON HOLD	+	The entry 7xyd is ON HOLD until 2024-12-01

	Authors:		Authors:

OCA: Protected "7xyd" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:05:17 GMT

Protected "7xyd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:05, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7xyd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jun 2022 04:05:16 GMT

New page: '''Unreleased structure''' The entry 7xyd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7xyd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7xyd - Revision history

OCA at 07:58, 6 December 2023

OCA at 05:44, 25 October 2023

OCA: Protected "7xyd" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7xyd is ON HOLD Authors: Description: Category: Unreleased Structures