OCA at 19:24, 19 October 2022

OCA — Wed, 19 Oct 2022 19:24:38 GMT

←Older revision		Revision as of 19:24, 19 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7y26 is ~~ON HOLD~~	+	==Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex==
		+	<StructureSection load='7y26' size='340' side='right'caption='[[7y26]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7y26]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y26 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y26 OCA], [https://pdbe.org/7y26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y26 RCSB], [https://www.ebi.ac.uk/pdbsum/7y26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y26 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein-coupled receptors (GPCRs) modulate every aspect of physiological functions mainly through activating heterotrimeric G proteins. A majority of GPCRs promiscuously couple to multiple G protein subtypes. Here we validate that in addition to the well-known Gi/o pathway, somatostatin receptor 2 and 5 (SSTR2 and SSTR5) couple to the Gq/11 pathway and show that smaller ligands preferentially activate the Gi/o pathway. We further determined cryo-electron microscopy structures of the SSTR2Go and SSTR2Gq complexes bound to octreotide and SST-14. Structural and functional analysis revealed that G protein selectivity of SSTRs is not only determined by structural elements in the receptor-G protein interface, but also by the conformation of the agonist-binding pocket. Accordingly, smaller ligands fail to stabilize a broader agonist-binding pocket of SSTRs that is required for efficient Gq/11 coupling but not Gi/o coupling. Our studies facilitate the design of drugs with selective G protein signaling to improve therapeutic efficacy.

-	~~Authors~~:	+	Molecular basis for the selective G protein signaling of somatostatin receptors.,Chen S, Teng X, Zheng S Nat Chem Biol. 2022 Sep 22. pii: 10.1038/s41589-022-01130-3. doi:, 10.1038/s41589-022-01130-3. PMID:36138141<ref>PMID:36138141</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7y26" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen S]]
		+	[[Category: Zheng S]]

OCA: Protected "7y26" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2022 03:59:37 GMT

Protected "7y26" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:59, 15 June 2022

OCA: New page: '''Unreleased structure''' The entry 7y26 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Jun 2022 03:59:36 GMT

New page: '''Unreleased structure''' The entry 7y26 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7y26 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7y26 - Revision history

OCA at 19:24, 19 October 2022

OCA: Protected "7y26" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7y26 is ON HOLD Authors: Description: Category: Unreleased Structures