OCA at 09:58, 20 December 2023

OCA — Wed, 20 Dec 2023 09:58:55 GMT

←Older revision		Revision as of 09:58, 20 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7y2h is ~~ON HOLD until Paper Publication~~	+	==Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 180 K==
-		+	<StructureSection load='7y2h' size='340' side='right'caption='[[7y2h]], [[Resolution\|resolution]] 1.20Å' scene=''>
-	~~Authors~~: ~~Kim~~, C.U., ~~Kim~~, J.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7y2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y2H FirstGlance]. <br>
-	~~Description~~: ~~Zn-Carbonic Anhydrase~~ II ~~complexed~~ with ~~3NPA after UV at 180 K~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: Kim~~, J.K~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y2h OCA], [https://pdbe.org/7y2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y2h RCSB], [https://www.ebi.ac.uk/pdbsum/7y2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y2h ProSAT]</span></td></tr>
-	[[Category: Kim~~, C.U~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Kim CU]]
		+	[[Category: Kim JK]]

OCA at 03:53, 20 July 2022

OCA — Wed, 20 Jul 2022 03:53:33 GMT

←Older revision		Revision as of 03:53, 20 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7y2h is ON HOLD	+	The entry 7y2h is ON HOLD until Paper Publication

	Authors: Kim, C.U., Kim, J.K.		Authors: Kim, C.U., Kim, J.K.

OCA: Protected "7y2h" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2022 04:00:05 GMT

Protected "7y2h" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:00, 15 June 2022

OCA: New page: '''Unreleased structure''' The entry 7y2h is ON HOLD Authors: Kim, C.U., Kim, J.K. Description: Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 180 K [[Category: Unreleased St...

OCA — Wed, 15 Jun 2022 04:00:03 GMT

New page: '''Unreleased structure''' The entry 7y2h is ON HOLD Authors: Kim, C.U., Kim, J.K. Description: Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 180 K [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 7y2h is ON HOLD

Authors: Kim, C.U., Kim, J.K.

Description: Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 180 K
[[Category: Unreleased Structures]]
[[Category: Kim, J.K]]
[[Category: Kim, C.U]]

7y2h - Revision history

OCA at 09:58, 20 December 2023

OCA at 03:53, 20 July 2022

OCA: Protected "7y2h" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7y2h is ON HOLD Authors: Kim, C.U., Kim, J.K. Description: Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 180 K [[Category: Unreleased St...