OCA at 06:08, 19 July 2023

OCA — Wed, 19 Jul 2023 06:08:59 GMT

←Older revision		Revision as of 06:08, 19 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7y6k is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody==
-		+	<StructureSection load='7y6k' size='340' side='right'caption='[[7y6k]], [[Resolution\|resolution]] 3.34Å' scene=''>
-	~~Authors: Yoo, Y., Cho, H.S.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7y6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y6K FirstGlance]. <br>
-	~~Description:~~ Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.34Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Yoo, Y~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y6k OCA], [https://pdbe.org/7y6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y6k RCSB], [https://www.ebi.ac.uk/pdbsum/7y6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y6k ProSAT]</span></td></tr>
-	[[Category: Cho~~, H.S~~]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Cho HS]]
		+	[[Category: Yoo Y]]

OCA at 14:55, 6 July 2022

OCA — Wed, 06 Jul 2022 14:55:55 GMT

←Older revision		Revision as of 14:55, 6 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7y6k is ON HOLD	+	The entry 7y6k is ON HOLD until Paper Publication

	Authors: Yoo, Y., Cho, H.S.		Authors: Yoo, Y., Cho, H.S.

OCA: Protected "7y6k" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2022 06:09:19 GMT

Protected "7y6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:09, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 7y6k is ON HOLD Authors: Yoo, Y., Cho, H.S. Description: Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific ...

OCA — Wed, 29 Jun 2022 06:09:18 GMT

New page: '''Unreleased structure''' The entry 7y6k is ON HOLD Authors: Yoo, Y., Cho, H.S. Description: Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific ...

New page

'''Unreleased structure'''

The entry 7y6k is ON HOLD

Authors: Yoo, Y., Cho, H.S.

Description: Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody
[[Category: Unreleased Structures]]
[[Category: Yoo, Y]]
[[Category: Cho, H.S]]

7y6k - Revision history

OCA at 06:08, 19 July 2023

OCA at 14:55, 6 July 2022

OCA: Protected "7y6k" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7y6k is ON HOLD Authors: Yoo, Y., Cho, H.S. Description: Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific ...