OCA at 10:33, 2 August 2023

OCA — Wed, 02 Aug 2023 10:33:02 GMT

←Older revision		Revision as of 10:33, 2 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7y72 is ~~ON HOLD until 2024~~-09-27	+	==SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface)==
-		+	<StructureSection load='7y72' size='340' side='right'caption='[[7y72]], [[Resolution\|resolution]] 4.03Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7y72]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y72 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.03Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y72 OCA], [https://pdbe.org/7y72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y72 RCSB], [https://www.ebi.ac.uk/pdbsum/7y72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y72 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Au GG]]
		+	[[Category: Barr J]]
		+	[[Category: Bloom JD]]
		+	[[Category: Chen M]]
		+	[[Category: Chen S]]
		+	[[Category: Cheng S]]
		+	[[Category: Chia WN]]
		+	[[Category: Chung AW]]
		+	[[Category: Fibriansah G]]
		+	[[Category: Greaney AJ]]
		+	[[Category: Lim BL]]
		+	[[Category: Lok SM]]
		+	[[Category: Lopez E]]
		+	[[Category: Lye D]]
		+	[[Category: Ng TS]]
		+	[[Category: Paradkar P]]
		+	[[Category: Peiris M]]
		+	[[Category: Sia WR]]
		+	[[Category: Starr TN]]
		+	[[Category: Tan AWK]]
		+	[[Category: Tan CW]]
		+	[[Category: Wang LF]]
		+	[[Category: Yap WC]]
		+	[[Category: Yeoh AYY]]
		+	[[Category: Young B]]
		+	[[Category: Zhang J]]
		+	[[Category: Zhu F]]

OCA at 05:19, 3 May 2023

OCA — Wed, 03 May 2023 05:19:06 GMT

←Older revision		Revision as of 05:19, 3 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7y72 is ON HOLD until ~~Paper Publication~~	+	The entry 7y72 is ON HOLD until 2024-09-27

	Authors:		Authors:

OCA at 03:58, 13 July 2022

OCA — Wed, 13 Jul 2022 03:58:47 GMT

←Older revision		Revision as of 03:58, 13 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7y72 is ON HOLD	+	The entry 7y72 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7y72" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2022 06:10:00 GMT

Protected "7y72" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:10, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 7y72 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Jun 2022 06:09:59 GMT

New page: '''Unreleased structure''' The entry 7y72 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7y72 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7y72 - Revision history

OCA at 10:33, 2 August 2023

OCA at 05:19, 3 May 2023

OCA at 03:58, 13 July 2022

OCA: Protected "7y72" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7y72 is ON HOLD Authors: Description: Category: Unreleased Structures