OCA at 12:36, 22 February 2023

OCA — Wed, 22 Feb 2023 12:36:06 GMT

←Older revision		Revision as of 12:36, 22 February 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7y7j is ~~ON HOLD until Paper Publication~~	+	==SARS-CoV-2 S trimer in complex with 1F Fab==
-		+	<StructureSection load='7y7j' size='340' side='right'caption='[[7y7j]], [[Resolution\|resolution]] 4.80Å' scene=''>
-	~~Authors~~: ~~Zhao~~, S., ~~Liu~~, F., ~~Yang, X~~., ~~Zhong, G~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7y7j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y7J FirstGlance]. <br>
-	~~Description~~: ~~SARS~~-~~CoV~~-~~2 S~~ trimer in ~~complex with 1F Fab~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y7j OCA], [https://pdbe.org/7y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y7j RCSB], [https://www.ebi.ac.uk/pdbsum/7y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y7j ProSAT]</span></td></tr>
-	[[Category: ~~Yang, X~~]]	+	</table>
-	[[Category: Liu, F]]	+	== Function ==
-	[[Category: Zhao, S]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: Zhong, G]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Liu F]]
		+	[[Category: Yang X]]
		+	[[Category: Zhao S]]
		+	[[Category: Zhong G]]

OCA at 05:17, 31 August 2022

OCA — Wed, 31 Aug 2022 05:17:17 GMT

←Older revision		Revision as of 05:17, 31 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7y7j is ON HOLD	+	The entry 7y7j is ON HOLD until Paper Publication

	Authors: Zhao, S., Liu, F., Yang, X., Zhong, G.		Authors: Zhao, S., Liu, F., Yang, X., Zhong, G.

OCA: Protected "7y7j" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2022 06:10:48 GMT

Protected "7y7j" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:10, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 7y7j is ON HOLD Authors: Zhao, S., Liu, F., Yang, X., Zhong, G. Description: SARS-CoV-2 S trimer in complex with 1F Fab [[Category: Unreleased Stru...

OCA — Wed, 29 Jun 2022 06:10:47 GMT

New page: '''Unreleased structure''' The entry 7y7j is ON HOLD Authors: Zhao, S., Liu, F., Yang, X., Zhong, G. Description: SARS-CoV-2 S trimer in complex with 1F Fab [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 7y7j is ON HOLD

Authors: Zhao, S., Liu, F., Yang, X., Zhong, G.

Description: SARS-CoV-2 S trimer in complex with 1F Fab
[[Category: Unreleased Structures]]
[[Category: Yang, X]]
[[Category: Liu, F]]
[[Category: Zhao, S]]
[[Category: Zhong, G]]

7y7j - Revision history

OCA at 12:36, 22 February 2023

OCA at 05:17, 31 August 2022

OCA: Protected "7y7j" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7y7j is ON HOLD Authors: Zhao, S., Liu, F., Yang, X., Zhong, G. Description: SARS-CoV-2 S trimer in complex with 1F Fab [[Category: Unreleased Stru...