OCA at 05:21, 9 August 2023

OCA — Wed, 09 Aug 2023 05:21:34 GMT

←Older revision		Revision as of 05:21, 9 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ybm is ~~ON HOLD~~	+	==SARS-CoV-2 C.1.2 variant spike (Close state)==
-		+	<StructureSection load='7ybm' size='340' side='right'caption='[[7ybm]], [[Resolution\|resolution]] 3.45Å' scene=''>
-	~~Authors~~: ~~Wang~~, X., Fu, W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ybm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YBM FirstGlance]. <br>
-	~~Description~~: ~~SARS-CoV-2 C~~.1.~~2 variant spike~~ (~~Close~~ state)	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.45Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Fu, W]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ybm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ybm OCA], [https://pdbe.org/7ybm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ybm RCSB], [https://www.ebi.ac.uk/pdbsum/7ybm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ybm ProSAT]</span></td></tr>
-	[[Category: Wang, X]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Fu W]]
		+	[[Category: Wang X]]

OCA: Protected "7ybm" [edit=sysop:move=sysop]

OCA — Wed, 06 Jul 2022 14:59:44 GMT

Protected "7ybm" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 6 July 2022

OCA: New page: '''Unreleased structure''' The entry 7ybm is ON HOLD Authors: Wang, X., Fu, W. Description: SARS-CoV-2 C.1.2 variant spike (Close state) Category: Unreleased Structures [[Category:...

OCA — Wed, 06 Jul 2022 14:59:43 GMT

New page: '''Unreleased structure''' The entry 7ybm is ON HOLD Authors: Wang, X., Fu, W. Description: SARS-CoV-2 C.1.2 variant spike (Close state) Category: Unreleased Structures [[Category:...

New page

'''Unreleased structure'''

The entry 7ybm is ON HOLD

Authors: Wang, X., Fu, W.

Description: SARS-CoV-2 C.1.2 variant spike (Close state)
[[Category: Unreleased Structures]]
[[Category: Fu, W]]
[[Category: Wang, X]]

7ybm - Revision history

OCA at 05:21, 9 August 2023

OCA: Protected "7ybm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ybm is ON HOLD Authors: Wang, X., Fu, W. Description: SARS-CoV-2 C.1.2 variant spike (Close state) Category: Unreleased Structures [[Category:...