OCA at 06:28, 26 October 2022

OCA — Wed, 26 Oct 2022 06:28:25 GMT

←Older revision		Revision as of 06:28, 26 October 2022
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-	'''Unreleased structure'''

-	The ~~entry~~ 7yer is ~~ON HOLD until Paper Publication~~	+	==The structure of EBOV L-VP35 complex==
-		+	<StructureSection load='7yer' size='340' side='right'caption='[[7yer]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7yer]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus Ebola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YER FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yer OCA], [https://pdbe.org/7yer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yer RCSB], [https://www.ebi.ac.uk/pdbsum/7yer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yer ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1C4HDB0_9MONO A0A1C4HDB0_9MONO] RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.[ARBA:ARBA00003132][PIRNR:PIRNR037548] RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.[PIRNR:PIRNR037548]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ebola virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Bin Y]]
		+	[[Category: Qi P]]
		+	[[Category: Yi S]]

OCA at 03:29, 18 August 2022

OCA — Thu, 18 Aug 2022 03:29:41 GMT

←Older revision		Revision as of 03:29, 18 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7yer is ON HOLD	+	The entry 7yer is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7yer" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2022 04:02:52 GMT

Protected "7yer" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:02, 13 July 2022

OCA: New page: '''Unreleased structure''' The entry 7yer is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Jul 2022 04:02:51 GMT

New page: '''Unreleased structure''' The entry 7yer is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7yer is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7yer - Revision history

OCA at 06:28, 26 October 2022

OCA at 03:29, 18 August 2022

OCA: Protected "7yer" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7yer is ON HOLD Authors: Description: Category: Unreleased Structures