7ygv - Revision history

OCA at 19:47, 29 May 2024

OCA — Wed, 29 May 2024 19:47:23 GMT

←Older revision		Revision as of 19:47, 29 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ygv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YGV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ygv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YGV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ygv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ygv OCA], [https://pdbe.org/7ygv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ygv RCSB], [https://www.ebi.ac.uk/pdbsum/7ygv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ygv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ygv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ygv OCA], [https://pdbe.org/7ygv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ygv RCSB], [https://www.ebi.ac.uk/pdbsum/7ygv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ygv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:50, 15 March 2023

OCA — Wed, 15 Mar 2023 09:50:29 GMT

←Older revision		Revision as of 09:50, 15 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ygv is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the Ca2+-bound EFhd1/Swiprosin-2==
		+	<StructureSection load='7ygv' size='340' side='right'caption='[[7ygv]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7ygv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YGV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ygv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ygv OCA], [https://pdbe.org/7ygv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ygv RCSB], [https://www.ebi.ac.uk/pdbsum/7ygv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ygv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EFHD1_MOUSE EFHD1_MOUSE] Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (PubMed:16336229).[UniProtKB:Q9BUP0]<ref>PMID:16336229</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EF-hand proteins, which contain a Ca(2+)-binding EF-hand motif, are involved in regulating diverse cellular functions. Ca(2+) binding induces conformational changes that modulate the activities of EF-hand proteins. Moreover, these proteins occasionally modify their activities by coordinating metals other than Ca(2+), including Mg(2+), Pb(2+) and Zn(2+), within their EF-hands. EFhd1 and EFhd2 are homologous EF-hand proteins with similar structures. Although separately localized within cells, both are actin-binding proteins that modulate F-actin rearrangement through Ca(2+)-independent actin-binding and Ca(2+)-dependent actin-bundling activity. Although Ca(2+) is known to affect the activities of EFhd1 and EFhd2, it is not known whether their actin-related activities are affected by other metals. Here, the crystal structures of the EFhd1 and EFhd2 core domains coordinating Zn(2+) ions within their EF-hands are reported. The presence of Zn(2+) within EFhd1 and EFhd2 was confirmed by analyzing anomalous signals and the difference between anomalous signals using data collected at the peak positions as well as low-energy remote positions at the Zn K-edge. EFhd1 and EFhd2 were also found to exhibit Zn(2+)-independent actin-binding and Zn(2+)-dependent actin-bundling activity. This suggests the actin-related activities of EFhd1 and EFhd2 could be regulated by Zn(2+) as well as Ca(2+).

-	~~Authors~~:	+	Structural and biochemical insights into Zn(2+)-bound EF-hand proteins, EFhd1 and EFhd2.,Mun SA, Park J, Kang JY, Park T, Jin M, Yang J, Eom SH IUCrJ. 2023 Mar 1;10(Pt 2):233-245. doi: 10.1107/S2052252523001501. PMID:36862489<ref>PMID:36862489</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7ygv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Eom SH]]
		+	[[Category: Jin M]]
		+	[[Category: Kang JY]]
		+	[[Category: Mun SA]]
		+	[[Category: Park J]]
		+	[[Category: Park T]]
		+	[[Category: Ynag J]]

OCA at 03:30, 18 August 2022

OCA — Thu, 18 Aug 2022 03:30:26 GMT

←Older revision		Revision as of 03:30, 18 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ygv is ON HOLD	+	The entry 7ygv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ygv" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:01:16 GMT

Protected "7ygv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:01, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 7ygv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jul 2022 04:01:14 GMT

New page: '''Unreleased structure''' The entry 7ygv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ygv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]