7yhk - Revision history

OCA at 06:19, 19 July 2023

OCA — Wed, 19 Jul 2023 06:19:06 GMT

←Older revision		Revision as of 06:19, 19 July 2023
Line 1:		Line 1:

-	====	+	==Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in complex with neutralizing antibody 12H5==
-	<StructureSection load='7yhk' size='340' side='right'caption='[[7yhk]]' scene=''>	+	<StructureSection load='7yhk' size='340' side='right'caption='[[7yhk]], [[Resolution\|resolution]] 3.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7yhk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Beijing/262/1995(H1N1)) Influenza A virus (A/Beijing/262/1995(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YHK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yhk OCA], [https://pdbe.org/7yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yhk RCSB], [https://www.ebi.ac.uk/pdbsum/7yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yhk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.14Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yhk OCA], [https://pdbe.org/7yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yhk RCSB], [https://www.ebi.ac.uk/pdbsum/7yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yhk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6WG01_9INFA Q6WG01_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Li S]]
		+	[[Category: Li T]]
		+	[[Category: Sun H]]
		+	[[Category: Xue W]]
		+	[[Category: Zheng Q]]

OCA at 06:24, 18 August 2022

OCA — Thu, 18 Aug 2022 06:24:12 GMT

←Older revision		Revision as of 06:24, 18 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7yhk ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7yhk' size='340' side='right'caption='[[7yhk]]' scene=''>
-	~~Authors~~: ~~Zheng, Q~~.~~, Li, S~~.~~, Li, T., Xue, W., Sun, H~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Cryo~~-~~EM structure of~~ the ~~HA trimer of A~~/~~Beijing~~/~~262~~/~~1995(H1N1) in complex with neutralizing antibody 12H5~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yhk OCA], [https://pdbe.org/7yhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yhk RCSB], [https://www.ebi.ac.uk/pdbsum/7yhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yhk ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Li, S~~]]	+	__TOC__
-	[[~~Category~~: ~~Xue~~, W]]	+	</StructureSection>
-	[~~[Category~~: Li, T]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zheng, Q~~]]	+	[[Category: Z-disk]]
-	[[Category: ~~Sun, H~~]]	+

OCA: Protected "7yhk" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:04:28 GMT

Protected "7yhk" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 7yhk is ON HOLD Authors: Zheng, Q., Li, S., Li, T., Xue, W., Sun, H. Description: Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in...

OCA — Wed, 20 Jul 2022 04:04:26 GMT

New page: '''Unreleased structure''' The entry 7yhk is ON HOLD Authors: Zheng, Q., Li, S., Li, T., Xue, W., Sun, H. Description: Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in...

New page

'''Unreleased structure'''

The entry 7yhk is ON HOLD

Authors: Zheng, Q., Li, S., Li, T., Xue, W., Sun, H.

Description: Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in complex with neutralizing antibody 12H5
[[Category: Unreleased Structures]]
[[Category: Li, S]]
[[Category: Xue, W]]
[[Category: Li, T]]
[[Category: Zheng, Q]]
[[Category: Sun, H]]