OCA at 05:22, 9 August 2023

OCA — Wed, 09 Aug 2023 05:22:12 GMT

←Older revision		Revision as of 05:22, 9 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7yn0 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of MERS-CoV spike protein, all RBD-down conformation==
-		+	<StructureSection load='7yn0' size='340' side='right'caption='[[7yn0]], [[Resolution\|resolution]] 4.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7yn0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YN0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yn0 OCA], [https://pdbe.org/7yn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yn0 RCSB], [https://www.ebi.ac.uk/pdbsum/7yn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yn0 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human betacoronavirus 2c EMC/2012]]
		+	[[Category: Large Structures]]
		+	[[Category: Chang NE]]
		+	[[Category: Draczkowski P]]
		+	[[Category: Hsu STD]]
		+	[[Category: Weng ZW]]
		+	[[Category: Yang TJ]]

OCA at 06:24, 21 September 2022

OCA — Wed, 21 Sep 2022 06:24:08 GMT

←Older revision		Revision as of 06:24, 21 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7yn0 is ON HOLD	+	The entry 7yn0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7yn0" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2022 03:43:36 GMT

Protected "7yn0" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:43, 3 August 2022

OCA: New page: '''Unreleased structure''' The entry 7yn0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Aug 2022 03:43:35 GMT

New page: '''Unreleased structure''' The entry 7yn0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7yn0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7yn0 - Revision history

OCA at 05:22, 9 August 2023

OCA at 06:24, 21 September 2022

OCA: Protected "7yn0" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7yn0 is ON HOLD Authors: Description: Category: Unreleased Structures