OCA at 11:18, 1 February 2023

OCA — Wed, 01 Feb 2023 11:18:42 GMT

←Older revision		Revision as of 11:18, 1 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ytd is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of four human FcmR bound to IgM-Fc/J==
-		+	<StructureSection load='7ytd' size='340' side='right'caption='[[7ytd]], [[Resolution\|resolution]] 3.71Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ytd]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YTD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ytd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ytd OCA], [https://pdbe.org/7ytd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ytd RCSB], [https://www.ebi.ac.uk/pdbsum/7ytd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ytd ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/IGHM_HUMAN IGHM_HUMAN] Autosomal agammaglobulinemia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:8890099</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHM_HUMAN IGHM_HUMAN] IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.<ref>PMID:3137579</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Li Y]]
		+	[[Category: Shen H]]
		+	[[Category: Xiao J]]

OCA at 04:28, 28 September 2022

OCA — Wed, 28 Sep 2022 04:28:05 GMT

←Older revision		Revision as of 04:28, 28 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ytd is ON HOLD	+	The entry 7ytd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ytd" [edit=sysop:move=sysop]

OCA — Thu, 25 Aug 2022 03:37:01 GMT

Protected "7ytd" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:37, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 7ytd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 25 Aug 2022 03:36:59 GMT

New page: '''Unreleased structure''' The entry 7ytd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ytd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ytd - Revision history

OCA at 11:18, 1 February 2023

OCA at 04:28, 28 September 2022

OCA: Protected "7ytd" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ytd is ON HOLD Authors: Description: Category: Unreleased Structures