OCA at 06:17, 6 September 2023

OCA — Wed, 06 Sep 2023 06:17:58 GMT

←Older revision		Revision as of 06:17, 6 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7z1x is ~~ON HOLD~~	+	==Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6==
-		+	<StructureSection load='7z1x' size='340' side='right'caption='[[7z1x]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7z1x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z1X FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z1x OCA], [https://pdbe.org/7z1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z1x RCSB], [https://www.ebi.ac.uk/pdbsum/7z1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z1x ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GSDMD_HUMAN GSDMD_HUMAN] Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).[UniProtKB:Q9D8T2]<ref>PMID:26375003</ref> <ref>PMID:26375259</ref> <ref>PMID:27281216</ref> <ref>PMID:27418190</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Geyer M]]
		+	[[Category: Hagelueken G]]
		+	[[Category: Kopp A]]

OCA at 02:17, 25 May 2023

OCA — Thu, 25 May 2023 02:17:48 GMT

←Older revision		Revision as of 02:17, 25 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7z1x is ON HOLD ~~until Paper Publication~~	+	The entry 7z1x is ON HOLD

	Authors:		Authors:

OCA at 09:47, 30 March 2022

OCA — Wed, 30 Mar 2022 09:47:08 GMT

←Older revision		Revision as of 09:47, 30 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7z1x is ON HOLD	+	The entry 7z1x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7z1x" [edit=sysop:move=sysop]

OCA — Wed, 09 Mar 2022 05:09:43 GMT

Protected "7z1x" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 9 March 2022

OCA: New page: '''Unreleased structure''' The entry 7z1x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 09 Mar 2022 05:09:42 GMT

New page: '''Unreleased structure''' The entry 7z1x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7z1x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7z1x - Revision history

OCA at 06:17, 6 September 2023

OCA at 02:17, 25 May 2023

OCA at 09:47, 30 March 2022

OCA: Protected "7z1x" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7z1x is ON HOLD Authors: Description: Category: Unreleased Structures