7z50 - Revision history

OCA at 13:28, 1 February 2024

OCA — Thu, 01 Feb 2024 13:28:59 GMT

←Older revision		Revision as of 13:28, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7z50]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7z50]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HA2D_MOUSE HA2D_MOUSE]]	+	[https://www.uniprot.org/uniprot/HA2D_MOUSE HA2D_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7z50" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7z50" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:05, 8 September 2022

OCA — Thu, 08 Sep 2022 05:05:25 GMT

←Older revision		Revision as of 05:05, 8 September 2022
Line 1:		Line 1:

	==Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.==		==Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.==
-	<StructureSection load='7z50' size='340' side='right'caption='[[7z50]]' scene=''>	+	<StructureSection load='7z50' size='340' side='right'caption='[[7z50]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7z50]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HA2D_MOUSE HA2D_MOUSE]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We recently provided evidence for promiscuous recognition of several different hybrid insulin peptides (HIPs) by the highly diabetogenic, I-A(g7)-restricted 4.1-T cell receptor (TCR). To understand the structural determinants of this phenomenon, we solved the structure of an agonistic HIP/I-A(g7) complex, both in isolation as well as bound to the 4.1-TCR. We find that HIP promiscuity of the 4.1-TCR is dictated, on the one hand, by an amino acid sequence pattern that ensures I-A(g7) binding and, on the other hand, by the presence of three acidic residues at positions P5, P7 and P8 that favor an optimal engagement by the 4.1-TCR's complementary determining regions. Surprisingly, comparison of the TCR-bound and unbound HIP/I-A(g7) structures reveals that 4.1-TCR binding triggers several novel and unique structural motions in both the I-A(g7) molecule and the peptide that are essential for docking. This observation indicates that the type 1 diabetes-associated I-A(g7) molecule is structurally malleable and that this plasticity allows the recognition of multiple peptides by individual TCRs that would otherwise be unable to do so.
		+
		+	Structural plasticity in I-A(g7) links autoreactivity to hybrid insulin peptides in type I diabetes.,Erausquin E, Serra P, Parras D, Santamaria P, Lopez-Sagaseta J Front Immunol. 2022 Jul 28;13:924311. doi: 10.3389/fimmu.2022.924311. eCollection, 2022. PMID:35967292<ref>PMID:35967292</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7z50" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Erausquin E]]		[[Category: Erausquin E]]
	[[Category: Lopez-Sagaseta J]]		[[Category: Lopez-Sagaseta J]]

OCA at 11:13, 31 August 2022

OCA — Wed, 31 Aug 2022 11:13:57 GMT

←Older revision		Revision as of 11:13, 31 August 2022
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-	====	+	==Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.==
	<StructureSection load='7z50' size='340' side='right'caption='[[7z50]]' scene=''>		<StructureSection load='7z50' size='340' side='right'caption='[[7z50]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z50 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Erausquin E]]
		+	[[Category: Lopez-Sagaseta J]]

OCA at 06:57, 20 July 2022

OCA — Wed, 20 Jul 2022 06:57:57 GMT

←Older revision		Revision as of 06:57, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7z50 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7z50' size='340' side='right'caption='[[7z50]]' scene=''>
-	~~Authors~~: ~~Lopez~~-~~Sagaseta, J~~.~~, Erausquin, E~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of the highly diabetogenic 4~~.1-~~T cell receptor targeting a hybrid insulin peptide bound to I-Ag7~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z50 OCA], [https://pdbe.org/7z50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z50 RCSB], [https://www.ebi.ac.uk/pdbsum/7z50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z50 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Erausquin, E~~]]	+	__TOC__
-	[[Category: ~~Lopez~~-~~Sagaseta, J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:01, 15 June 2022

OCA — Wed, 15 Jun 2022 04:01:38 GMT

←Older revision		Revision as of 04:01, 15 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7z50 is ON HOLD	+	The entry 7z50 is ON HOLD until Paper Publication

	Authors: Lopez-Sagaseta, J., Erausquin, E.		Authors: Lopez-Sagaseta, J., Erausquin, E.

OCA: Protected "7z50" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2022 05:17:48 GMT

Protected "7z50" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 16 March 2022

OCA: New page: '''Unreleased structure''' The entry 7z50 is ON HOLD Authors: Lopez-Sagaseta, J., Erausquin, E. Description: Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid...

OCA — Wed, 16 Mar 2022 05:17:47 GMT

New page: '''Unreleased structure''' The entry 7z50 is ON HOLD Authors: Lopez-Sagaseta, J., Erausquin, E. Description: Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid...

New page

'''Unreleased structure'''

The entry 7z50 is ON HOLD

Authors: Lopez-Sagaseta, J., Erausquin, E.

Description: Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.
[[Category: Unreleased Structures]]
[[Category: Erausquin, E]]
[[Category: Lopez-Sagaseta, J]]