OCA at 05:57, 8 September 2022

OCA — Thu, 08 Sep 2022 05:57:06 GMT

←Older revision		Revision as of 05:57, 8 September 2022
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-	====	+	==CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation==
-	<StructureSection load='7z86' size='340' side='right'caption='[[7z86]]' scene=''>	+	<StructureSection load='7z86' size='340' side='right'caption='[[7z86]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7z86]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z86 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z86 OCA], [https://pdbe.org/7z86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z86 RCSB], [https://www.ebi.ac.uk/pdbsum/7z86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z86 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z86 OCA], [https://pdbe.org/7z86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z86 RCSB], [https://www.ebi.ac.uk/pdbsum/7z86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z86 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/WAC_BPT4 WAC_BPT4]] Chaperone responsible for attachment of long tail fibers to virus particle. Forms the fibrous structure on the neck of the virion called whiskers. During phage assembly, 6 fibritin molecules attach to each virion neck through their N-terminal domains, to form a collar with six fibers ('whiskers').[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia virus T4]]
		+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Naismith JH]]
		+	[[Category: Weckener M]]

OCA at 05:19, 13 July 2022

OCA — Wed, 13 Jul 2022 05:19:16 GMT

←Older revision		Revision as of 05:19, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7z86 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7z86' size='340' side='right'caption='[[7z86]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z86 OCA], [https://pdbe.org/7z86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z86 RCSB], [https://www.ebi.ac.uk/pdbsum/7z86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z86 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7z86" [edit=sysop:move=sysop]

OCA — Wed, 23 Mar 2022 10:11:25 GMT

Protected "7z86" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:11, 23 March 2022

OCA: New page: '''Unreleased structure''' The entry 7z86 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 23 Mar 2022 10:11:24 GMT

New page: '''Unreleased structure''' The entry 7z86 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7z86 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7z86 - Revision history

OCA at 05:57, 8 September 2022

OCA at 05:19, 13 July 2022

OCA: Protected "7z86" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7z86 is ON HOLD Authors: Description: Category: Unreleased Structures