7zdr - Revision history

OCA at 17:41, 1 November 2023

OCA — Wed, 01 Nov 2023 17:41:22 GMT

←Older revision		Revision as of 17:41, 1 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zdr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZDR FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zdr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZDR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zdr OCA], [https://pdbe.org/7zdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zdr RCSB], [https://www.ebi.ac.uk/pdbsum/7zdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zdr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zdr OCA], [https://pdbe.org/7zdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zdr RCSB], [https://www.ebi.ac.uk/pdbsum/7zdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zdr ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:23, 19 April 2023

OCA — Wed, 19 Apr 2023 09:23:14 GMT

←Older revision		Revision as of 09:23, 19 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zdr is ~~ON HOLD until Paper Publication~~	+	==IF(apo/as isolated) conformation of CydDC mutant (H85A.C) in AMP-PNP(CydD) bound state (Dataset-16)==
-		+	<StructureSection load='7zdr' size='340' side='right'caption='[[7zdr]], [[Resolution\|resolution]] 3.05Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zdr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZDR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zdr OCA], [https://pdbe.org/7zdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zdr RCSB], [https://www.ebi.ac.uk/pdbsum/7zdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zdr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CYDC_ECOLI CYDC_ECOLI] Part of the ABC transporter complex CydDC that exports the reduced low-molecular-weight thiols cysteine and glutathione to the periplasm (PubMed:12393891, PubMed:16040611). Export of these thiol-containing redox-active molecules may be crucial for redox homeostasis in the periplasm, permitting correct assembly of various respiratory complexes and formation of correct disulfide bonds in periplasmic and secreted proteins (Probable). CydC contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation (PubMed:24958725). Required for the assembly of functional cytochrome bd-type quinol oxidases and periplasmic c-type cytochromes (PubMed:3032907, PubMed:7934832, PubMed:8181727, PubMed:15470119). Overexpression of CydDC under anaerobic conditions also results in the formation of a heme biosynthesis-derived pigment, P-574 (PubMed:12375104). CydDC binds heme b, but heme is probably not transported by the complex and instead has a role in regulating ATPase activity (PubMed:24958725).<ref>PMID:12375104</ref> <ref>PMID:12393891</ref> <ref>PMID:15470119</ref> <ref>PMID:16040611</ref> <ref>PMID:24958725</ref> <ref>PMID:3032907</ref> <ref>PMID:7934832</ref> <ref>PMID:8181727</ref> <ref>PMID:12393891</ref> <ref>PMID:16040611</ref> <ref>PMID:31279084</ref> Conversely, a more recent study suggests an alternative function of CydDC: authors suggest that CydDC does not mediate the export of L-cysteine but rather reduces cytoplasmic L-cystine to L-cysteine (PubMed:32900959). The principle function of CydDC would be to maintain the reduced state of cytoplasmic L-cysteine, thereby providing an important connection between sulfur metabolism, oxidative stress and resistance to antibiotics (PubMed:32900959).<ref>PMID:32900959</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Large Structures]]
		+	[[Category: Safarian S]]
		+	[[Category: Wu D]]

OCA at 10:39, 27 April 2022

OCA — Wed, 27 Apr 2022 10:39:31 GMT

←Older revision		Revision as of 10:39, 27 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zdr is ON HOLD	+	The entry 7zdr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7zdr" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2022 09:24:47 GMT

Protected "7zdr" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 6 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zdr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Apr 2022 09:24:46 GMT

New page: '''Unreleased structure''' The entry 7zdr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7zdr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]