7zej - Revision history

OCA at 13:31, 1 February 2024

OCA — Thu, 01 Feb 2024 13:31:24 GMT

←Older revision		Revision as of 13:31, 1 February 2024
Line 1:		Line 1:

	==Crystal structure of the human MGC45594 gene product in complex with celecoxib.==		==Crystal structure of the human MGC45594 gene product in complex with celecoxib.==
-	<StructureSection load='7zej' size='340' side='right'caption='[[7zej]]' scene=''>	+	<StructureSection load='7zej' size='340' side='right'caption='[[7zej]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEL:4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE'>CEL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith C]]		[[Category: Arrowsmith C]]

OCA at 12:55, 4 May 2022

OCA — Wed, 04 May 2022 12:55:29 GMT

←Older revision		Revision as of 12:55, 4 May 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7zej ~~is ON HOLD~~	+	==Crystal structure of the human MGC45594 gene product in complex with celecoxib.==
-		+	<StructureSection load='7zej' size='340' side='right'caption='[[7zej]]' scene=''>
-	~~Authors~~: ~~Shafqat, N~~.~~, Yue, W~~.W.~~, Koekemoer, L~~.~~, Niesen, F~~.~~, Ugochukwu, E~~.~~, Vollmar, M~~.~~, Weigelt, J~~.~~, Krojer, T~~., ~~Pike, A~~.~~, Chaikaud, A~~.~~, Von Delft, F~~., ~~Arrowsmith, C~~., ~~Bountra, C~~.~~, Edwards, A~~., ~~Opperman, U~~., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the human MGC45594 gene product in complex with celecoxib~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Chaikaud, A~~]]	+	__TOC__
-	[[Category: ~~Niesen, F~~]]	+	</StructureSection>
-	[[Category: ~~Yue, W.W~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Arrowsmith C]]
-	[[Category: Koekemoer, L]]	+	[[Category: Bountra C]]
-	[[Category: ~~Arrowsmith, C~~]]	+	[[Category: Chaikaud A]]
-	[[Category: ~~Pike, A~~]]	+	[[Category: Edwards A]]
-	[[Category: ~~Shafqat, N~~]]	+	[[Category: Koekemoer L]]
-	[[Category: ~~Edwards,~~ A]]	+	[[Category: Krojer T]]
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Niesen F]]
-	[[Category: ~~Krojer, T~~]]	+	[[Category: Opperman U]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Pike A]]
-	[[Category: ~~Opperman, U~~]]	+	[[Category: Shafqat N]]
-	[[Category: ~~Ugochukwu, E~~]]	+	[[Category: Ugochukwu E]]
-	[[Category: ~~Bountra, C]]~~	+	[[Category: Vollmar M]]
-	~~[[Category: Vollmar, M~~]]	+	[[Category: Von Delft F]]
		+	[[Category: Weigelt J]]
		+	[[Category: Yue WW]]

OCA at 01:48, 21 April 2022

OCA — Thu, 21 Apr 2022 01:48:17 GMT

←Older revision		Revision as of 01:48, 21 April 2022
Line 3:		Line 3:
	The entry 7zej is ON HOLD		The entry 7zej is ON HOLD

-	Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud, A., Von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Opperman, U.	+	Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud, A., Von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Opperman, U., Structural Genomics Consortium (SGC)

	Description: Crystal structure of the human MGC45594 gene product in complex with celecoxib.		Description: Crystal structure of the human MGC45594 gene product in complex with celecoxib.
Line 16:		Line 16:
	[[Category: Shafqat, N]]		[[Category: Shafqat, N]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
		+	[[Category: Structural Genomics Consortium (Sgc)]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
-	[[Category: Opperman, U]]
	[[Category: Weigelt, J]]		[[Category: Weigelt, J]]
		+	[[Category: Opperman, U]]
	[[Category: Ugochukwu, E]]		[[Category: Ugochukwu, E]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Vollmar, M]]		[[Category: Vollmar, M]]

OCA: Protected "7zej" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2022 09:26:19 GMT

Protected "7zej" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 6 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zej is ON HOLD Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud,...

OCA — Wed, 06 Apr 2022 09:26:18 GMT

New page: '''Unreleased structure''' The entry 7zej is ON HOLD Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud,...

New page

'''Unreleased structure'''

The entry 7zej is ON HOLD

Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud, A., Von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Opperman, U.

Description: Crystal structure of the human MGC45594 gene product in complex with celecoxib.
[[Category: Unreleased Structures]]
[[Category: Chaikaud, A]]
[[Category: Niesen, F]]
[[Category: Yue, W.W]]
[[Category: Von Delft, F]]
[[Category: Koekemoer, L]]
[[Category: Arrowsmith, C]]
[[Category: Pike, A]]
[[Category: Shafqat, N]]
[[Category: Edwards, A]]
[[Category: Krojer, T]]
[[Category: Opperman, U]]
[[Category: Weigelt, J]]
[[Category: Ugochukwu, E]]
[[Category: Bountra, C]]
[[Category: Vollmar, M]]