OCA at 09:23, 19 April 2023

OCA — Wed, 19 Apr 2023 09:23:41 GMT

←Older revision		Revision as of 09:23, 19 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zi4 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of the human INO80 complex bound to a WT nucleosome==
-		+	<StructureSection load='7zi4' size='340' side='right'caption='[[7zi4]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zi4]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZI4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zi4 OCA], [https://pdbe.org/7zi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zi4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zi4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RUVB1_HUMAN RUVB1_HUMAN] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> May be able to bind plasminogen at cell surface and enhance plasminogen activation.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ayala R]]
		+	[[Category: Bartke T]]
		+	[[Category: McCormack EA]]
		+	[[Category: Tvardovskiy A]]
		+	[[Category: Vance NR]]
		+	[[Category: Wigley DB]]
		+	[[Category: Willhoft O]]
		+	[[Category: Zhang X]]

OCA at 16:30, 27 July 2022

OCA — Wed, 27 Jul 2022 16:30:29 GMT

←Older revision		Revision as of 16:30, 27 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zi4 is ON HOLD	+	The entry 7zi4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:14, 29 June 2022

OCA — Wed, 29 Jun 2022 06:14:05 GMT

←Older revision		Revision as of 06:14, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zi4 is ON HOLD ~~until sometime in the future~~	+	The entry 7zi4 is ON HOLD

	Authors:		Authors:

OCA at 11:46, 4 May 2022

OCA — Wed, 04 May 2022 11:46:26 GMT

←Older revision		Revision as of 11:46, 4 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zi4 is ON HOLD	+	The entry 7zi4 is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "7zi4" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2022 08:51:21 GMT

Protected "7zi4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:51, 13 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zi4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Apr 2022 08:51:20 GMT

New page: '''Unreleased structure''' The entry 7zi4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page