OCA at 13:32, 1 February 2024

OCA — Thu, 01 Feb 2024 13:32:38 GMT

←Older revision		Revision as of 13:32, 1 February 2024
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	==Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi==		==Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi==
-	<StructureSection load='7zjc' size='340' side='right'caption='[[7zjc]]' scene=''>	+	<StructureSection load='7zjc' size='340' side='right'caption='[[7zjc]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjc OCA], [https://pdbe.org/7zjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjc RCSB], [https://www.ebi.ac.uk/pdbsum/7zjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjc ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjc OCA], [https://pdbe.org/7zjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjc RCSB], [https://www.ebi.ac.uk/pdbsum/7zjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LIP14_BORBU LIP14_BORBU] Outer membrane lipoprotein that could act as a component of a potential toxin-antitoxin system in B.burgdorferi which could serve as a plasmid stabilization mechanism in a growing bacterial population.<ref>PMID:35215098</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lyme disease is caused by the spirochete Borrelia burgdorferi, which can be transmitted to a mammalian host when infected Ixodes ticks feed. B. burgdorferi has many unique characteristics, such as the presence of at least 130 different lipoproteins, which is considerably more than any other known bacterium. Moreover, the B. burgdorferi genome is relatively small (1.5 Mbp) but at the same time it is quite complicated because it comprises a chromosome and 21 linear and circular plasmids. B. burgdorferi is also rich in paralogous proteins; in total, there are approximately 150 paralogous gene families. Equally important is the fact that there is still no vaccine against the Lyme disease. To better understand the role of lipoproteins in this unique bacterium, we solved the crystal structure of the outer membrane lipoprotein BBA14, which is coded on the relatively stable linear plasmid 54 (lp54). BBA14 does not share sequence identity with any other known proteins, and it is one of the ten members of the paralogous gene family 143 (PFam143). PFam143 members are known as orfD proteins from a genetic locus, designated 2.9. The obtained crystal structure revealed similarity to the antitoxin from the epsilon/zeta toxin-antitoxin system. The results of this study help to characterize BBA14 and to clarify the role of PFam143 in the lifecycle of B. burgdorferi.
		+
		+	Structural Analysis of the Outer Membrane Lipoprotein BBA14 (OrfD) and the Corresponding Paralogous Gene Family 143 (PFam143) from Borrelia burgdorferi.,Akopjana I, Brangulis K Pathogens. 2022 Jan 26;11(2). pii: pathogens11020154. doi:, 10.3390/pathogens11020154. PMID:35215098<ref>PMID:35215098</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7zjc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Borreliella burgdorferi B31]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brangulis K]]		[[Category: Brangulis K]]

OCA at 09:48, 22 June 2022

OCA — Wed, 22 Jun 2022 09:48:09 GMT

←Older revision		Revision as of 09:48, 22 June 2022
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-	'''Unreleased structure'''

-	~~The entry 7zjc is ON HOLD~~	+	==Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi==
-		+	<StructureSection load='7zjc' size='340' side='right'caption='[[7zjc]]' scene=''>
-	~~Authors: Brangulis, K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJC FirstGlance]. <br>
-	~~Description:~~ Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjc OCA], [https://pdbe.org/7zjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjc RCSB], [https://www.ebi.ac.uk/pdbsum/7zjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Brangulis, K]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brangulis K]]

OCA: Protected "7zjc" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:49:30 GMT

Protected "7zjc" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:49, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zjc is ON HOLD Authors: Brangulis, K. Description: Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi [[Ca...

OCA — Thu, 21 Apr 2022 01:49:29 GMT

New page: '''Unreleased structure''' The entry 7zjc is ON HOLD Authors: Brangulis, K. Description: Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi [[Ca...

New page

'''Unreleased structure'''

The entry 7zjc is ON HOLD

Authors: Brangulis, K.

Description: Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi
[[Category: Unreleased Structures]]
[[Category: Brangulis, K]]

7zjc - Revision history

OCA at 13:32, 1 February 2024

OCA at 09:48, 22 June 2022

OCA: Protected "7zjc" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7zjc is ON HOLD Authors: Brangulis, K. Description: Crystal structure (native) of outer surface protein BBA14 (OrfD) from Borrelia burgdorferi [[Ca...