7zl4 - Revision history

OCA at 03:25, 8 September 2022

OCA — Thu, 08 Sep 2022 03:25:25 GMT

←Older revision		Revision as of 03:25, 8 September 2022
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	==Cryo-EM structure of archaic chaperone-usher Csu pilus of Acinetobacter baumannii==		==Cryo-EM structure of archaic chaperone-usher Csu pilus of Acinetobacter baumannii==
-	<StructureSection load='7zl4' size='340' side='right'caption='[[7zl4]]' scene=''>	+	<StructureSection load='7zl4' size='340' side='right'caption='[[7zl4]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl4 OCA], [https://pdbe.org/7zl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl4 OCA], [https://pdbe.org/7zl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0A6F8TDQ5_ACIBA A0A6F8TDQ5_ACIBA]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adhesive pili assembled via the chaperone-usher pathway (CUP) are hair-like appendages that mediate host tissue colonization and biofilm formation of Gram-negative bacteria (1-3). Archaic CUP pili, the most diverse and widespread CUP adhesins, are promising vaccine and drug targets due to their prevalence in the most troublesome multidrug-resistant (MDR) pathogens (1,4,5). However, their architecture and assembly-secretion process remain unknown. Here, we present the 3.4 A resolution cryo-electron microscopy structure of the prototypical archaic Csu pilus that mediates biofilm formation of Acinetobacter baumannii, a notorious MDR nosocomial pathogen. In contrast to the thick helical tubes of the classical type 1 and P pili, archaic pili assemble into a conceptually novel ultrathin zigzag architecture secured by an elegant clinch mechanism. The molecular clinch provides the pilus with high mechanical stability as well as superelasticity, a property observed now for the first time in biomolecules, while enabling a more economical and faster pilus production. Furthermore, we demonstrate that clinch formation at the cell surface drives pilus secretion through the outer membrane. These findings suggest that clinch-formation inhibitors might represent a new strategy to fight MDR bacterial infections.
		+
		+	Archaic chaperone-usher pili self-secrete into superelastic zigzag springs.,Pakharukova N, Malmi H, Tuittila M, Dahlberg T, Ghosal D, Chang YW, Myint SL, Paavilainen S, Knight SD, Lamminmaki U, Uhlin BE, Andersson M, Jensen G, Zavialov AV Nature. 2022 Jul 19. pii: 10.1038/s41586-022-05095-0. doi:, 10.1038/s41586-022-05095-0. PMID:35853476<ref>PMID:35853476</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7zl4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acinetobacter baumannii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chang YW]]		[[Category: Chang YW]]

OCA at 04:55, 3 August 2022

OCA — Wed, 03 Aug 2022 04:55:37 GMT

←Older revision		Revision as of 04:55, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7zl4 is ~~ON HOLD~~	+	==Cryo-EM structure of archaic chaperone-usher Csu pilus of Acinetobacter baumannii==
-		+	<StructureSection load='7zl4' size='340' side='right'caption='[[7zl4]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl4 OCA], [https://pdbe.org/7zl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl4 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chang YW]]
		+	[[Category: Ghosal D]]
		+	[[Category: Jensen GJ]]
		+	[[Category: Malmi H]]
		+	[[Category: Paavilainen S]]
		+	[[Category: Pakharukova N]]
		+	[[Category: Tuittila M]]
		+	[[Category: Zavialov AV]]

OCA at 16:30, 27 July 2022

OCA — Wed, 27 Jul 2022 16:30:39 GMT

←Older revision		Revision as of 16:30, 27 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zl4 is ON HOLD ~~until Paper Publication~~	+	The entry 7zl4 is ON HOLD

	Authors:		Authors:

OCA at 04:09, 8 June 2022

OCA — Wed, 08 Jun 2022 04:09:41 GMT

←Older revision		Revision as of 04:09, 8 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zl4 is ON HOLD	+	The entry 7zl4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7zl4" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:53:17 GMT

Protected "7zl4" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:53, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zl4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 21 Apr 2022 01:53:16 GMT

New page: '''Unreleased structure''' The entry 7zl4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7zl4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]