7zm1 - Revision history

OCA at 08:04, 7 February 2024

OCA — Wed, 07 Feb 2024 08:04:36 GMT

←Older revision		Revision as of 08:04, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZM1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZM1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IY8:methoxy-[(~{E},3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]tridec-11-enyl]phosphinous+acid'>IY8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IY8:methoxy-[(~{E},3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]tridec-11-enyl]phosphinous+acid'>IY8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zm1 OCA], [https://pdbe.org/7zm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7zm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zm1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zm1 OCA], [https://pdbe.org/7zm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7zm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zm1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 19:35, 19 October 2022

OCA — Wed, 19 Oct 2022 19:35:13 GMT

←Older revision		Revision as of 19:35, 19 October 2022
Line 8:		Line 8:
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU]] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref>	+	[https://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:21, 28 September 2022

OCA — Wed, 28 Sep 2022 06:21:25 GMT

←Older revision		Revision as of 06:21, 28 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7zm1 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of HsaD from Mycobacterium tuberculosis in complex with Cyclophostin-like inhibitor CyC7b==
-		+	<StructureSection load='7zm1' size='340' side='right'caption='[[7zm1]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~Authors~~: ~~Barelier~~, S., ~~Roig~~-~~Zamboni~~, V., ~~Cavalier~~, J.F., ~~Sulzenbacher, G~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZM1 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~HsaD from Mycobacterium tuberculosis~~ in ~~complex with Cyclophostin~~-~~like inhibitor CyC7b~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IY8:methoxy-[(~{E},3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]tridec-11-enyl]phosphinous+acid'>IY8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zm1 OCA], [https://pdbe.org/7zm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7zm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zm1 ProSAT]</span></td></tr>
-	[[Category: ~~Cavalier, J.F~~]]	+	</table>
-	[[Category: ~~Roig-Zamboni, V~~]]	+	== Function ==
-	[[Category: ~~Sulzenbacher, G~~]]	+	[[https://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU]] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref>
-	[[Category: ~~Barelier, S~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis H37Rv]]
		+	[[Category: Barelier S]]
		+	[[Category: Cavalier JF]]
		+	[[Category: Roig-Zamboni V]]
		+	[[Category: Sulzenbacher G]]

OCA: Protected "7zm1" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2022 10:40:56 GMT

Protected "7zm1" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:40, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zm1 is ON HOLD until Paper Publication Authors: Barelier, S., Roig-Zamboni, V., Cavalier, J.F., Sulzenbacher, G. Description: Crystal structure of...

OCA — Wed, 27 Apr 2022 10:40:55 GMT

New page: '''Unreleased structure''' The entry 7zm1 is ON HOLD until Paper Publication Authors: Barelier, S., Roig-Zamboni, V., Cavalier, J.F., Sulzenbacher, G. Description: Crystal structure of...

New page

'''Unreleased structure'''

The entry 7zm1 is ON HOLD until Paper Publication

Authors: Barelier, S., Roig-Zamboni, V., Cavalier, J.F., Sulzenbacher, G.

Description: Crystal structure of HsaD from Mycobacterium tuberculosis in complex with Cyclophostin-like inhibitor CyC7b
[[Category: Unreleased Structures]]
[[Category: Cavalier, J.F]]
[[Category: Roig-Zamboni, V]]
[[Category: Sulzenbacher, G]]
[[Category: Barelier, S]]