7znl - Revision history

OCA at 06:57, 18 May 2023

OCA — Thu, 18 May 2023 06:57:22 GMT

←Older revision		Revision as of 06:57, 18 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7znl is ~~ON HOLD~~	+	==Structure of the human TREX core THO-UAP56 complex==
-		+	<StructureSection load='7znl' size='340' side='right'caption='[[7znl]], [[Resolution\|resolution]] 3.45Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7znl]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZNL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7znl OCA], [https://pdbe.org/7znl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7znl RCSB], [https://www.ebi.ac.uk/pdbsum/7znl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7znl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/THOC1_HUMAN THOC1_HUMAN] Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref> Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Pacheco-Fiallos FB]]
		+	[[Category: Plaschka C]]
		+	[[Category: Vorlaender MK]]

OCA at 05:19, 3 May 2023

OCA — Wed, 03 May 2023 05:19:32 GMT

←Older revision		Revision as of 05:19, 3 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7znl is ON HOLD ~~until sometime in the future~~	+	The entry 7znl is ON HOLD

	Authors:		Authors:

OCA at 09:14, 22 February 2023

OCA — Wed, 22 Feb 2023 09:14:51 GMT

←Older revision		Revision as of 09:14, 22 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7znl is ON HOLD	+	The entry 7znl is ON HOLD until sometime in the future

	Authors:		Authors:

OCA at 08:23, 15 February 2023

OCA — Wed, 15 Feb 2023 08:23:43 GMT

←Older revision		Revision as of 08:23, 15 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7znl is ON HOLD ~~until sometime in the future~~	+	The entry 7znl is ON HOLD

	Authors:		Authors:

OCA at 05:06, 12 May 2022

OCA — Thu, 12 May 2022 05:06:22 GMT

←Older revision		Revision as of 05:06, 12 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7znl is ON HOLD	+	The entry 7znl is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "7znl" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2022 10:43:13 GMT

Protected "7znl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7znl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Apr 2022 10:43:12 GMT

New page: '''Unreleased structure''' The entry 7znl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7znl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]