7zs3 - Revision history

OCA at 13:34, 1 February 2024

OCA — Thu, 01 Feb 2024 13:34:06 GMT

←Older revision		Revision as of 13:34, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_trichocarpa Populus trichocarpa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_trichocarpa Populus trichocarpa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZS3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.603Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zs3 OCA], [https://pdbe.org/7zs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zs3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zs3 OCA], [https://pdbe.org/7zs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zs3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B9HKX9_POPTR B9HKX9_POPTR]]	+	[https://www.uniprot.org/uniprot/B9HKX9_POPTR B9HKX9_POPTR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 19:01, 7 September 2022

OCA — Wed, 07 Sep 2022 19:01:34 GMT

←Older revision		Revision as of 19:01, 7 September 2022
Line 9:		Line 9:
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/B9HKX9_POPTR B9HKX9_POPTR]]		[[https://www.uniprot.org/uniprot/B9HKX9_POPTR B9HKX9_POPTR]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutathione transferases (GSTs) constitute a widespread superfamily of enzymes notably involved in xenobiotic detoxification and/or in specialized metabolism. Populus trichocarpa genome (V4.1 assembly, Phytozome 13) consists of 74 genes coding for full-length GSTs and ten likely pseudogenes. These GSTs are divided into 11 classes, in which the tau class (GSTU) is the most abundant with 54 isoforms. PtGSTU19 and 20, two paralogs sharing more than 91% sequence identity (95% of sequence similarity), would have diverged from a common ancestor of P. trichocarpa and P. yatungensis species. These enzymes display the distinctive glutathione (GSH)-conjugation and peroxidase activities against model substrates. The resolution of the crystal structures of these proteins revealed significant structural differences despite their high sequence identity. PtGSTU20 has a well-defined deep pocket in the active site whereas the bottom of this pocket is disordered in PtGSTU19. In a screen of potential ligands, we were able to identify an interaction with flavonoids. Some of them, previously identified in poplar (chrysin, galangin, and pinocembrin), inhibited GSH-conjugation activity of both enzymes with a more pronounced effect on PtGSTU20. The crystal structures of PtGSTU20 complexed with these molecules provide evidence for their potential involvement in flavonoid transport in P. trichocarpa.
		+
		+	Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids.,Sylvestre-Gonon E, Morette L, Viloria M, Mathiot S, Boutilliat A, Favier F, Rouhier N, Didierjean C, Hecker A Front Mol Biosci. 2022 Aug 12;9:958586. doi: 10.3389/fmolb.2022.958586., eCollection 2022. PMID:36032685<ref>PMID:36032685</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7zs3" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:51, 7 September 2022

OCA — Wed, 07 Sep 2022 16:51:22 GMT

←Older revision		Revision as of 16:51, 7 September 2022
Line 1:		Line 1:

	==Crystal structure of poplar glutathione transferase U19==		==Crystal structure of poplar glutathione transferase U19==
-	<StructureSection load='7zs3' size='340' side='right'caption='[[7zs3]]' scene=''>	+	<StructureSection load='7zs3' size='340' side='right'caption='[[7zs3]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZS3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_trichocarpa Populus trichocarpa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZS3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zs3 OCA], [https://pdbe.org/7zs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zs3 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zs3 OCA], [https://pdbe.org/7zs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zs3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/B9HKX9_POPTR B9HKX9_POPTR]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Populus trichocarpa]]
	[[Category: Didierjean C]]		[[Category: Didierjean C]]
	[[Category: Favier F]]		[[Category: Favier F]]

OCA at 06:58, 20 July 2022

OCA — Wed, 20 Jul 2022 06:58:19 GMT

←Older revision		Revision as of 06:58, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7zs3 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of poplar glutathione transferase U19==
-		+	<StructureSection load='7zs3' size='340' side='right'caption='[[7zs3]]' scene=''>
-	~~Authors~~: ~~Didierjean~~, C., ~~Favier~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZS3 FirstGlance]. <br>
-	~~Description: Crystal structure of poplar glutathione transferase U19~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zs3 OCA], [https://pdbe.org/7zs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zs3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zs3 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Didierjean, C]]	+	__TOC__
-	[[Category: Favier, F]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Didierjean C]]
		+	[[Category: Favier F]]

OCA at 06:52, 25 May 2022

OCA — Wed, 25 May 2022 06:52:56 GMT

←Older revision		Revision as of 06:52, 25 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zs3 is ON HOLD	+	The entry 7zs3 is ON HOLD until Paper Publication

	Authors: Didierjean, C., Favier, F.		Authors: Didierjean, C., Favier, F.
Line 7:		Line 7:
	Description: Crystal structure of poplar glutathione transferase U19		Description: Crystal structure of poplar glutathione transferase U19
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Favier, F]]
	[[Category: Didierjean, C]]		[[Category: Didierjean, C]]
		+	[[Category: Favier, F]]

OCA: Protected "7zs3" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2022 05:10:56 GMT

Protected "7zs3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:10, 12 May 2022

OCA: New page: '''Unreleased structure''' The entry 7zs3 is ON HOLD Authors: Didierjean, C., Favier, F. Description: Crystal structure of poplar glutathione transferase U19 [[Category: Unreleased Str...

OCA — Thu, 12 May 2022 05:10:55 GMT

New page: '''Unreleased structure''' The entry 7zs3 is ON HOLD Authors: Didierjean, C., Favier, F. Description: Crystal structure of poplar glutathione transferase U19 [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 7zs3 is ON HOLD

Authors: Didierjean, C., Favier, F.

Description: Crystal structure of poplar glutathione transferase U19
[[Category: Unreleased Structures]]
[[Category: Favier, F]]
[[Category: Didierjean, C]]