7zsl - Revision history

OCA at 08:06, 7 February 2024

OCA — Wed, 07 Feb 2024 08:06:11 GMT

←Older revision		Revision as of 08:06, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zsl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZSL FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zsl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZSL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JTO:[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic+acid'>JTO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JTO:[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic+acid'>JTO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zsl OCA], [https://pdbe.org/7zsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zsl RCSB], [https://www.ebi.ac.uk/pdbsum/7zsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zsl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zsl OCA], [https://pdbe.org/7zsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zsl RCSB], [https://www.ebi.ac.uk/pdbsum/7zsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zsl ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
		+
		+	==See Also==
		+	*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:57, 18 May 2023

OCA — Thu, 18 May 2023 06:57:47 GMT

←Older revision		Revision as of 06:57, 18 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zsl is ~~ON HOLD until Paper Publication~~	+	==human purine nucleoside phosphorylase in complex with JS-196==
-		+	<StructureSection load='7zsl' size='340' side='right'caption='[[7zsl]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Djukic~~, S., ~~Pachl~~, P., ~~Rezacova~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zsl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZSL FirstGlance]. <br>
-	~~Description~~: ~~human~~ purine nucleoside phosphorylase in ~~complex~~ with JS-~~196~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JTO:[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic+acid'>JTO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zsl OCA], [https://pdbe.org/7zsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zsl RCSB], [https://www.ebi.ac.uk/pdbsum/7zsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zsl ProSAT]</span></td></tr>
-	[[Category: ~~Rezacova, P~~]]	+	</table>
-	[[Category: Pachl, P]]	+	== Disease ==
-	[[Category: ~~Djukic, S~~]]	+	[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Djukic S]]
		+	[[Category: Pachl P]]
		+	[[Category: Rezacova P]]

OCA at 04:13, 8 June 2022

OCA — Wed, 08 Jun 2022 04:13:51 GMT

←Older revision		Revision as of 04:13, 8 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zsl is ON HOLD	+	The entry 7zsl is ON HOLD until Paper Publication

	Authors: Djukic, S., Pachl, P., Rezacova, P.		Authors: Djukic, S., Pachl, P., Rezacova, P.

OCA: Protected "7zsl" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2022 09:18:45 GMT

Protected "7zsl" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:18, 18 May 2022

OCA: New page: '''Unreleased structure''' The entry 7zsl is ON HOLD Authors: Djukic, S., Pachl, P., Rezacova, P. Description: human purine nucleoside phosphorylase in complex with JS-196 [[Category: ...

OCA — Wed, 18 May 2022 09:18:44 GMT

New page: '''Unreleased structure''' The entry 7zsl is ON HOLD Authors: Djukic, S., Pachl, P., Rezacova, P. Description: human purine nucleoside phosphorylase in complex with JS-196 [[Category: ...

New page

'''Unreleased structure'''

The entry 7zsl is ON HOLD

Authors: Djukic, S., Pachl, P., Rezacova, P.

Description: human purine nucleoside phosphorylase in complex with JS-196
[[Category: Unreleased Structures]]
[[Category: Rezacova, P]]
[[Category: Pachl, P]]
[[Category: Djukic, S]]