7zvd - Revision history

OCA at 05:51, 23 August 2023

OCA — Wed, 23 Aug 2023 05:51:42 GMT

←Older revision		Revision as of 05:51, 23 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zvd is ~~ON HOLD until Paper Publication~~	+	==K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+==
-		+	<StructureSection load='7zvd' size='340' side='right'caption='[[7zvd]], [[Resolution\|resolution]] 2.46Å' scene=''>
-	~~Authors~~: Wu, F., ~~Muskat, N~~.H., ~~Nudelman~~, H., ~~Shahar, A~~., ~~Arbely, E~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZVD FirstGlance]. <br>
-	~~Description~~: ~~K89 acetylated glucose~~-~~6-phosphate dehydrogenase~~ (G6PD) in a ~~complex~~ with ~~structural NADP+~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.46Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	[[Category: Arbely, E]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zvd OCA], [https://pdbe.org/7zvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zvd RCSB], [https://www.ebi.ac.uk/pdbsum/7zvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zvd ProSAT]</span></td></tr>
-	[[Category: ~~Shahar, A~~]]	+	</table>
-	[[Category: Nudelman, H]]	+	== Disease ==
-	[[Category: ~~Wu, F~~]]	+	[https://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN] Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:[https://omim.org/entry/305900 305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.<ref>PMID:1611091</ref>
-	[[Category: ~~Muskat, N.H~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN] Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
		+	[[Category: Arbely E]]
		+	[[Category: Muskat NH]]
		+	[[Category: Nudelman H]]
		+	[[Category: Shahar A]]
		+	[[Category: Wu F]]

OCA at 04:04, 13 July 2022

OCA — Wed, 13 Jul 2022 04:04:52 GMT

←Older revision		Revision as of 04:04, 13 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zvd is ON HOLD	+	The entry 7zvd is ON HOLD until Paper Publication

	Authors: Wu, F., Muskat, N.H., Nudelman, H., Shahar, A., Arbely, E.		Authors: Wu, F., Muskat, N.H., Nudelman, H., Shahar, A., Arbely, E.
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	Description: K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+		Description: K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Arbely, E]]
	[[Category: Shahar, A]]		[[Category: Shahar, A]]
	[[Category: Nudelman, H]]		[[Category: Nudelman, H]]
-	[[Category: Muskat, N.H]]
-	[[Category: Arbely, E]]
	[[Category: Wu, F]]		[[Category: Wu, F]]
		+	[[Category: Muskat, N.H]]

OCA: Protected "7zvd" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2022 06:54:09 GMT

Protected "7zvd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:54, 25 May 2022

OCA: New page: '''Unreleased structure''' The entry 7zvd is ON HOLD Authors: Wu, F., Muskat, N.H., Nudelman, H., Shahar, A., Arbely, E. Description: K89 acetylated glucose-6-phosphate dehydrogenase (...

OCA — Wed, 25 May 2022 06:54:08 GMT

New page: '''Unreleased structure''' The entry 7zvd is ON HOLD Authors: Wu, F., Muskat, N.H., Nudelman, H., Shahar, A., Arbely, E. Description: K89 acetylated glucose-6-phosphate dehydrogenase (...

New page

'''Unreleased structure'''

The entry 7zvd is ON HOLD

Authors: Wu, F., Muskat, N.H., Nudelman, H., Shahar, A., Arbely, E.

Description: K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
[[Category: Unreleased Structures]]
[[Category: Shahar, A]]
[[Category: Nudelman, H]]
[[Category: Muskat, N.H]]
[[Category: Arbely, E]]
[[Category: Wu, F]]