7zwm - Revision history

OCA at 13:35, 1 February 2024

OCA — Thu, 01 Feb 2024 13:35:06 GMT

←Older revision		Revision as of 13:35, 1 February 2024
Line 1:		Line 1:

-	====	+	==Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3==
-	<StructureSection load='7zwm' size='340' side='right'caption='[[7zwm]]' scene=''>	+	<StructureSection load='7zwm' size='340' side='right'caption='[[7zwm]], [[Resolution\|resolution]] 3.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zwm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZWM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zwm OCA], [https://pdbe.org/7zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zwm RCSB], [https://www.ebi.ac.uk/pdbsum/7zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zwm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.69Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zwm OCA], [https://pdbe.org/7zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zwm RCSB], [https://www.ebi.ac.uk/pdbsum/7zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zwm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P4548_PLAF7 P4548_PLAF7] Gametocyte surface protein required for male fertility.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indeed, antibodies which bind Pfs48/45 can prevent transmission if ingested with the parasite as part of the mosquito bloodmeal. Here we present the structure of full-length Pfs48/45, showing its three domains to form a dynamic, planar, triangular arrangement. We reveal where transmission-blocking and non-blocking antibodies bind on Pfs48/45. Finally, we demonstrate that antibodies which bind across this molecule can be transmission-blocking. These studies will guide the development of future Pfs48/45-based vaccine immunogens.
		+
		+	Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.,Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK Nat Commun. 2022 Sep 24;13(1):5603. doi: 10.1038/s41467-022-33379-6. PMID:36153317<ref>PMID:36153317</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7zwm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Higgins MK]]
		+	[[Category: Ko KT]]
		+	[[Category: Lennartz FL]]

OCA at 09:48, 22 June 2022

OCA — Wed, 22 Jun 2022 09:48:35 GMT

←Older revision		Revision as of 09:48, 22 June 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7zwm ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7zwm' size='340' side='right'caption='[[7zwm]]' scene=''>
-	~~Authors~~: ~~Ko, K~~.T.~~, Lennartz, F~~.L.~~, Higgins, M~~.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Pfs48~~/~~45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zwm OCA], [https://pdbe.org/7zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zwm RCSB], [https://www.ebi.ac.uk/pdbsum/7zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zwm ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Higgins~~, M.K]]	+	__TOC__
-	[[Category: ~~Ko, K.T~~]]	+	</StructureSection>
-	[[Category: ~~Lennartz, F.L~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7zwm" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2022 06:56:41 GMT

Protected "7zwm" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:56, 25 May 2022

OCA: New page: '''Unreleased structure''' The entry 7zwm is ON HOLD Authors: Ko, K.T., Lennartz, F.L., Higgins, M.K. Description: Pfs48/45 central and C-terminal domains bound to Fab fragments of mon...

OCA — Wed, 25 May 2022 06:56:40 GMT

New page: '''Unreleased structure''' The entry 7zwm is ON HOLD Authors: Ko, K.T., Lennartz, F.L., Higgins, M.K. Description: Pfs48/45 central and C-terminal domains bound to Fab fragments of mon...

New page

'''Unreleased structure'''

The entry 7zwm is ON HOLD

Authors: Ko, K.T., Lennartz, F.L., Higgins, M.K.

Description: Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3
[[Category: Unreleased Structures]]
[[Category: Higgins, M.K]]
[[Category: Ko, K.T]]
[[Category: Lennartz, F.L]]