7zyf - Revision history

OCA at 13:35, 1 February 2024

OCA — Thu, 01 Feb 2024 13:35:42 GMT

←Older revision		Revision as of 13:35, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KFR:methyl+(2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate'>KFR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.81Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KFR:methyl+(2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate'>KFR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN]] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref>	+	[https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:50, 8 September 2022

OCA — Thu, 08 Sep 2022 04:50:19 GMT

←Older revision		Revision as of 04:50, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='7zyf' size='340' side='right'caption='[[7zyf]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='7zyf' size='340' side='right'caption='[[7zyf]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7zyf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KFR:methyl+(2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate'>KFR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KFR:methyl+(2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate'>KFR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5mj6\|5mj6]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN]] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref>	+	[[https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN]] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 7zyf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7zyf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Giastas, P]]	+	[[Category: Giastas P]]
-	[[Category: Mpakali, A]]	+	[[Category: Mpakali A]]
-	[[Category: Papakyriakou, A]]	+	[[Category: Papakyriakou A]]
-	[[Category: Stratikos, E]]	+	[[Category: Stratikos E]]
-	~~[[Category: Alpla hydroxy beta amino acid based inhibitor]]~~	+
-	~~[[Category: Bestatin analogue]]~~	+
-	~~[[Category: Hsplap]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Insulin regulated aminopeptidase]]~~	+
-	~~[[Category: Irap~~]]	+

OCA at 18:20, 27 July 2022

OCA — Wed, 27 Jul 2022 18:20:49 GMT

←Older revision		Revision as of 18:20, 27 July 2022
Line 1:		Line 1:

	==Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.==		==Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.==
-	<StructureSection load='7zyf' size='340' side='right'caption='[[7zyf]]' scene=''>	+	<StructureSection load='7zyf' size='340' side='right'caption='[[7zyf]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7zyf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KFR:methyl+(2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate'>KFR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5mj6\|5mj6]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN]] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin-regulated aminopeptidase (IRAP); however, reports on clinically relevant inhibitors are limited. Here we report a new synthetic approach of high diastereo- and regioselectivity for functionalization of the alpha-hydroxy-beta-amino acid scaffold of bestatin. Stereochemistry and mechanism of inhibition were investigated by a high-resolution X-ray crystal structure of ERAP1 in complex with a micromolar inhibitor. By exploring the P1 side-chain functionalities, we achieve significant potency and selectivity, and we report a cell-active, low-nanomolar inhibitor of IRAP with >120-fold selectivity over homologous enzymes. X-ray crystallographic analysis of IRAP in complex with this inhibitor suggest that interactions with the GAMEN loop is an unappreciated key determinant for potency and selectivity. Overall, our results suggest that alpha-hydroxy-beta-amino acid derivatives may constitute useful chemical tools and drug leads for this group of aminopeptidases.
		+
		+	Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.,Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou D, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E, Papakyriakou A J Med Chem. 2022 Jul 14. doi: 10.1021/acs.jmedchem.2c00904. PMID:35833347<ref>PMID:35833347</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7zyf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Giastas P]]	+	[[Category: Giastas, P]]
-	[[Category: Mpakali A]]	+	[[Category: Mpakali, A]]
-	[[Category: Papakyriakou A]]	+	[[Category: Papakyriakou, A]]
-	[[Category: Stratikos E]]	+	[[Category: Stratikos, E]]
		+	[[Category: Alpla hydroxy beta amino acid based inhibitor]]
		+	[[Category: Bestatin analogue]]
		+	[[Category: Hsplap]]
		+	[[Category: Hydrolase]]
		+	[[Category: Insulin regulated aminopeptidase]]
		+	[[Category: Irap]]

OCA at 06:58, 20 July 2022

OCA — Wed, 20 Jul 2022 06:58:34 GMT

←Older revision		Revision as of 06:58, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7zyf is ON HOLD until Paper Publication~~	+	==Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.==
-		+	<StructureSection load='7zyf' size='340' side='right'caption='[[7zyf]]' scene=''>
-	~~Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYF FirstGlance]. <br>
-	~~Description:~~ Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyf OCA], [https://pdbe.org/7zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyf RCSB], [https://www.ebi.ac.uk/pdbsum/7zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Papakyriakou, A~~]]	+	__TOC__
-	[[Category: Mpakali, A]]	+	</StructureSection>
-	[[Category: ~~Giastas, P~~]]	+	[[Category: Large Structures]]
-	[[Category: Stratikos, E]]	+	[[Category: Giastas P]]
		+	[[Category: Mpakali A]]
		+	[[Category: Papakyriakou A]]
		+	[[Category: Stratikos E]]

OCA at 04:04, 15 June 2022

OCA — Wed, 15 Jun 2022 04:04:33 GMT

←Older revision		Revision as of 04:04, 15 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zyf is ON HOLD	+	The entry 7zyf is ON HOLD until Paper Publication

	Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A.		Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A.

-	Description: Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar ~~alpla~~ hydroxy beta amino acid based inhibitor.	+	Description: Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Papakyriakou, A]]		[[Category: Papakyriakou, A]]

OCA: Protected "7zyf" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:17:54 GMT

Protected "7zyf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7zyf is ON HOLD Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A. Description: Insulin regulated aminopeptidase (IRAP) in complex ...

OCA — Wed, 08 Jun 2022 04:17:53 GMT

New page: '''Unreleased structure''' The entry 7zyf is ON HOLD Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A. Description: Insulin regulated aminopeptidase (IRAP) in complex ...

New page

'''Unreleased structure'''

The entry 7zyf is ON HOLD

Authors: Mpakali, A., Stratikos, E., Giastas, P., Papakyriakou, A.

Description: Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpla hydroxy beta amino acid based inhibitor.
[[Category: Unreleased Structures]]
[[Category: Papakyriakou, A]]
[[Category: Mpakali, A]]
[[Category: Giastas, P]]
[[Category: Stratikos, E]]