7zyp - Revision history

OCA at 08:07, 7 February 2024

OCA — Wed, 07 Feb 2024 08:07:47 GMT

←Older revision		Revision as of 08:07, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=R25:propan-2-yl+2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate'>R25</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=R25:propan-2-yl+2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate'>R25</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyp OCA], [https://pdbe.org/7zyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyp RCSB], [https://www.ebi.ac.uk/pdbsum/7zyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyp OCA], [https://pdbe.org/7zyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyp RCSB], [https://www.ebi.ac.uk/pdbsum/7zyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:27, 3 May 2023

OCA — Wed, 03 May 2023 07:27:38 GMT

←Older revision		Revision as of 07:27, 3 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zyp is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of EGFR-T790M/C797S in Complex with Reversible Aminopyrimidine 9==
-		+	<StructureSection load='7zyp' size='340' side='right'caption='[[7zyp]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Niggenaber~~, J., ~~Mueller~~, M.P., ~~Rauh~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYP FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of~~ EGFR-~~T790M~~/~~C797S~~ in ~~Complex~~ with ~~XXXX~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=R25:propan-2-yl+2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate'>R25</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyp OCA], [https://pdbe.org/7zyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyp RCSB], [https://www.ebi.ac.uk/pdbsum/7zyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyp ProSAT]</span></td></tr>
-	[[Category: ~~Niggenaber, J~~]]	+	</table>
-	[[Category: Mueller~~, M.P~~]]	+	== Disease ==
-	[[Category: Rauh, D]]	+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[https://omim.org/entry/211980 211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref> Isoform 2 may act as an antagonist of EGF action.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mueller MP]]
		+	[[Category: Niggenaber J]]
		+	[[Category: Rauh D]]

OCA at 07:10, 14 December 2022

OCA — Wed, 14 Dec 2022 07:10:45 GMT

←Older revision		Revision as of 07:10, 14 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zyp is ON HOLD	+	The entry 7zyp is ON HOLD until Paper Publication

	Authors: Niggenaber, J., Mueller, M.P., Rauh, D.		Authors: Niggenaber, J., Mueller, M.P., Rauh, D.

OCA at 04:40, 9 November 2022

OCA — Wed, 09 Nov 2022 04:40:51 GMT

←Older revision		Revision as of 04:40, 9 November 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zyp is ON HOLD ~~until Paper Publication~~	+	The entry 7zyp is ON HOLD

	Authors: Niggenaber, J., Mueller, M.P., Rauh, D.		Authors: Niggenaber, J., Mueller, M.P., Rauh, D.

OCA: Protected "7zyp" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:18:20 GMT

Protected "7zyp" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7zyp is ON HOLD until Paper Publication Authors: Niggenaber, J., Mueller, M.P., Rauh, D. Description: Crystal Structure of EGFR-T790M/C797S in Comp...

OCA — Wed, 08 Jun 2022 04:18:19 GMT

New page: '''Unreleased structure''' The entry 7zyp is ON HOLD until Paper Publication Authors: Niggenaber, J., Mueller, M.P., Rauh, D. Description: Crystal Structure of EGFR-T790M/C797S in Comp...

New page

'''Unreleased structure'''

The entry 7zyp is ON HOLD until Paper Publication

Authors: Niggenaber, J., Mueller, M.P., Rauh, D.

Description: Crystal Structure of EGFR-T790M/C797S in Complex with XXXX
[[Category: Unreleased Structures]]
[[Category: Niggenaber, J]]
[[Category: Mueller, M.P]]
[[Category: Rauh, D]]