8a5x - Revision history

OCA at 13:36, 1 February 2024

OCA — Thu, 01 Feb 2024 13:36:43 GMT

←Older revision		Revision as of 13:36, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A5X FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L6A:4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide'>L6A</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L6A:4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide'>L6A</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a5x OCA], [https://pdbe.org/8a5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a5x RCSB], [https://www.ebi.ac.uk/pdbsum/8a5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a5x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a5x OCA], [https://pdbe.org/8a5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a5x RCSB], [https://www.ebi.ac.uk/pdbsum/8a5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>		[https://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
		+
		+	==See Also==
		+	*[[Phosphatidylinositol 4-kinase\|Phosphatidylinositol 4-kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:35, 19 October 2022

OCA — Wed, 19 Oct 2022 19:35:48 GMT

←Older revision		Revision as of 19:35, 19 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8a5x is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of phosphatidyl inositol 4-kinase II beta in complex with MM1373==
-		+	<StructureSection load='8a5x' size='340' side='right'caption='[[8a5x]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8a5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A5X FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L6A:4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide'>L6A</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a5x OCA], [https://pdbe.org/8a5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a5x RCSB], [https://www.ebi.ac.uk/pdbsum/8a5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a5x ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Boura E]]
		+	[[Category: Klima M]]

OCA at 06:20, 29 June 2022

OCA — Wed, 29 Jun 2022 06:20:17 GMT

←Older revision		Revision as of 06:20, 29 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8a5x is ON HOLD	+	The entry 8a5x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8a5x" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2022 07:22:09 GMT

Protected "8a5x" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 22 June 2022

OCA: New page: '''Unreleased structure''' The entry 8a5x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Jun 2022 07:22:08 GMT

New page: '''Unreleased structure''' The entry 8a5x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a5x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]