8adm - Revision history

OCA at 08:11, 7 February 2024

OCA — Wed, 07 Feb 2024 08:11:08 GMT

←Older revision		Revision as of 08:11, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8adm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADM FirstGlance]. <br>		<table><tr><td colspan='2'>[[8adm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adm OCA], [https://pdbe.org/8adm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adm RCSB], [https://www.ebi.ac.uk/pdbsum/8adm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adm OCA], [https://pdbe.org/8adm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adm RCSB], [https://www.ebi.ac.uk/pdbsum/8adm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adm ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:03, 26 April 2023

OCA — Wed, 26 Apr 2023 17:03:19 GMT

←Older revision		Revision as of 17:03, 26 April 2023
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-	'''Unreleased structure'''

-	~~The entry 8adm is ON HOLD until Paper Publication~~	+	==Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer==
-		+	<StructureSection load='8adm' size='340' side='right'caption='[[8adm]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors: Centorrino, F., Ottmann, C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8adm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADM FirstGlance]. <br>
-	~~Description:~~ Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adm OCA], [https://pdbe.org/8adm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adm RCSB], [https://www.ebi.ac.uk/pdbsum/8adm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adm ProSAT]</span></td></tr>
-	[[Category: ~~Ottmann, C~~]]	+	</table>
-	[[Category: Centorrino, F]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Centorrino F]]
		+	[[Category: Ottmann C]]

OCA at 07:43, 24 November 2022

OCA — Thu, 24 Nov 2022 07:43:29 GMT

←Older revision		Revision as of 07:43, 24 November 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8adm is ON HOLD	+	The entry 8adm is ON HOLD until Paper Publication

	Authors: Centorrino, F., Ottmann, C.		Authors: Centorrino, F., Ottmann, C.

OCA: Protected "8adm" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:15:02 GMT

Protected "8adm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:15, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 8adm is ON HOLD Authors: Centorrino, F., Ottmann, C. Description: Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stab...

OCA — Wed, 20 Jul 2022 04:14:58 GMT

New page: '''Unreleased structure''' The entry 8adm is ON HOLD Authors: Centorrino, F., Ottmann, C. Description: Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stab...

New page

'''Unreleased structure'''

The entry 8adm is ON HOLD

Authors: Centorrino, F., Ottmann, C.

Description: Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer
[[Category: Unreleased Structures]]
[[Category: Ottmann, C]]
[[Category: Centorrino, F]]